PMID: 6112047May 11, 1981Paper

Beta-endorphin-induced increases in plasma epinephrine, norepinephrine and dopamine in rats: inhibition of adrenomedullary response by intracerebral somatostatin

Brain Research
G H van LoonD Ho

Abstract

Synthetic human beta-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied. Blockade of these endorphin effects by the prior systemic administration of naloxone supports mediation of the effects at opioid receptors. Acute systemic administration of guanethidine, which decreases norepinephrine release induced by sympathetic nerve stimulation, blunted the plasma norepinephrine response to intracerebral beta-endorphin. Thus, it seems likely that in addition to secretion by adrenal medulla a considerable portion of the beta-endorphin-induced increase in norepinephrine is derived from sympathetic nerve endings. Simultaneous intracisternal administration of another neuropeptide, somatostatin, together with beta-endorphin markedly inhibited the plasma epinephrine response to beta-endorphin, while decreasing the dopamine and norepinephrine responses to a much lesser degree. The dats suggest that beta-endorphin stimulates central sympathetic outflow to both adrenal medulla and sympathetic nerve endings, and further that somatostatin inhibits the effect of...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F BloomR Guillemin
Mar 1, 1978·The Journal of Physiology·H U BühlerG B Picotti
Sep 4, 1978·Life Sciences·G R van Loon, C Kim
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Jan 1, 1980·Endocrinology·G R van LoonC Kim
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Citations

Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J D WatsonC J Hinds
Mar 1, 1982·Physiology & Behavior·S Amir, M Bernstein
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·L DongG R Van Loon
Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·J R Wilson, B A Howard
Sep 1, 1986·Psychiatry Research·E GrofG R Van Loon
Oct 1, 1987·Journal of the Autonomic Nervous System·N M AppelG R Van Loon
Jan 1, 1993·Psychoneuroendocrinology·M Hoehe, T Duka
Nov 1, 1996·Journal of the American College of Cardiology·L GuastiA Venco
Sep 21, 2002·Autonomic Neuroscience : Basic & Clinical·Luigina GuastiSergio Cerutti
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y ShavitJ C Liebeskind
May 1, 1987·Acta Physiologica Scandinavica·M Delle, P Thorén
Dec 1, 1988·Acta Physiologica Scandinavica·M DelleS E Ricksten
May 1, 1985·Progress in Cardiovascular Diseases·M W JohnsonC S Wilcox
May 1, 1990·International Journal of Cardiology·A Y Lee
Jun 1, 1987·Hypertension·G Feuerstein, A L Siren
Sep 1, 1989·The American Journal of Physiology·J A NashN N Abumrad

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