Aug 1, 1976

beta-endorphin is a potent analgesic agent

Proceedings of the National Academy of Sciences of the United States of America
H H LohC H Li

Abstract

beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.

Mentioned in this Paper

Structure-Activity Relationship
Morphine Measurement
Brain
Analgesics
Oligopeptides
Opiates
Mouse, Inbred ICRC
Beta-Lipotropin
Beta-Endorphin
Pomc

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