PMID: 9526708Apr 4, 1998Paper

Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre- and postmenopausal women

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
M StomatiA D Genazzani

Abstract

Beta-endorphin (beta-EP) is a neuropeptide involved in several brain functions, regulating the reproductive axis and behavioral changes. Estrogens play a modulatory role on circulating levels of beta-EP in women. Previous clinical studies have demonstrated high plasma beta-EP levels in obese subjects and increased beta-EP release after an oral glucose tolerance test (OGTT) in normal or obese women. The aim of the present study was to evaluate plasma beta-endorphin levels in response to an OGTT in pre- and postmenopausal obese and non-obese women, in order to investigate if the decrease in gonadal steroid levels at menopause could modify in a different manner the control of beta-endorphin release in response to glucose administration. A group of 24 normal women (age range 45-55 years) were included in the study. The patients were subdivided in four groups of six subjects each: group A, premenopausal women with body mass index (BMI) < 25 (control); group B, premenopausal women with BMI > 25 (obese); group C, post-menopausal women with BMI < 25 (control); group D, postmenopausal women with BMI > 25 (obese). All women were studied between 8.30 and 9.00 am, after overnight fasting, and underwent an OGTT. In obese premenopausal women...Continue Reading

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Citations

Apr 3, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A GianniniA R Genazzani
Feb 26, 2000·European Journal of Clinical Investigation·C ZalavrasK N Malizos
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Georges KaramKarim Boudjema
May 24, 2005·CNS Spectrums·Andrea Riccardo GenazzaniMichele Luisi

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