PMID: 640774Feb 1, 1978Paper

beta-endorphin: synthesis and biological activity of shortened peptide chains

International Journal of Peptide and Protein Research
C H LiH H Loh

Abstract

Three analogs of beta-endorphin have been synthesized by the solid-phase method: betac-endorphin-(1--5)-(28--31), betac-endorphin-(6--31) and betah-endorphin-(1--5)-(16--31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than beta-endorphin. These data suggest that the entire beta-endorphin molecule is necessary for full in vivo analgesic activity.

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H H LohC H Li
Apr 11, 1977·Biochemical and Biophysical Research Communications·C H LiD Yamashiro
Jan 24, 1977·Biochemical and Biophysical Research Communications·B A DoneenC H Li
Mar 1, 1977·Journal of Medicinal Chemistry·C H LiH H Loh
Oct 18, 1976·Biochemical and Biophysical Research Communications·C H LiB A Doneen
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C H Li, D Chung
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N Ling, R Guillemin
Jan 1, 1975·International Journal of Peptide and Protein Research·J Blake, C H Li
Feb 21, 1973·Journal of the American Chemical Society·D Yamashiro, C H Li
Apr 1, 1974·Hoppe-Seyler's Zeitschrift für physiologische Chemie·B Hemmasi, E Bayer
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D Yamashiro, C H Li
Jan 1, 1971·International Journal of Protein Research·A Loffet
Jan 4, 1967·Journal of the American Chemical Society·J Lenard, A B Robinson

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Citations

May 1, 1978·International Journal of Peptide and Protein Research·J BlakeC H Li
Jan 1, 1979·International Journal of Peptide and Protein Research·D Yamashiro
Feb 1, 1980·International Journal of Peptide and Protein Research·J BlakeC H Li
Jul 1, 1978·International Journal of Peptide and Protein Research·H W YeungC H Li
Nov 1, 1985·International Journal of Peptide and Protein Research·M Westphal, C H Li
Jan 1, 1979·International Journal of Peptide and Protein Research·J BlakeC H Li
Aug 13, 1979·Biochemical and Biophysical Research Communications·P FerraraC H Li
Mar 29, 1983·Biochemical and Biophysical Research Communications·C L HoC H Li

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