Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes

American Journal of Physical Anthropology
L R BevilaquaMara H. Hutz

Abstract

Haplotypes derived from five polymorphic restriction sites in the beta-globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR). Eight haplotypes were identified. Haplotypes 2 ((+)----) and 6 (-)++(-)+) were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozygosity measured by the Gini-Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of an important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST') was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi-Mondé-speaking tribes were considered, this estimate was reduced to 0.030.

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Citations

Jun 22, 2000·American Journal of Physical Anthropology·V S MatteviM H Hutz
Jun 4, 2011·Genetics and Molecular Biology·Wellington Dos Santos SilvaCesar Koppe Grisolia
May 1, 1997·Annals of Human Biology·M H HutzC B Dejean
May 1, 1996·Annals of Human Biology·S M Callegari-JacquesL Schüler
Nov 18, 1998·Annals of Human Biology·D M ClariáC N Gardenal
Jun 29, 2000·Baillière's Clinical Haematology·J FlintJ B Clegg
Jul 6, 2002·Anais Da Academia Brasileira De Ciências·Francisco M Salzano
Jun 1, 1997·American Journal of Physical Anthropology·M C BortoliniT de A Weimer
Jan 1, 1997·American Journal of Human Biology : the Official Journal of the Human Biology Council·Dinorah Castro de GuerraFrancisco Mauro Salzano
Jan 1, 1998·American Journal of Human Biology : the Official Journal of the Human Biology Council·F M SalzanoC E A Coimbra
Sep 24, 2004·American Journal of Physical Anthropology·Fabiana B KohlrauschMara H Hutz
Oct 23, 1997·American Journal of Physical Anthropology·F M SalzanoC E Coimbra
Jun 29, 2007·American Journal of Physical Anthropology·Sidia M Callegari-JacquesMara H Hutz
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·A.R. Villalobos-ArámbulaB. Ibarra
Feb 11, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·João Farias GuerreiroJohn B Clegg
Jun 18, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Julio Da LuzMónica Sans

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