Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung

Cancer Immunology, Immunotherapy : CII
Matthew P AlexanderDavid W Mullins

Abstract

β-Glucan is a naturally occurring glucose polysaccharide with immunostimulatory activity in both infection and malignancy. β-Glucan's antitumor effects have been attributed to the enhancement of complement receptor 3-dependent cellular cytotoxicity, as well as modulation of suppressive and stimulatory myeloid subsets, which in turn enhances antitumor T cell immunity. In the present study, we demonstrate antitumor efficacy of yeast-derived β-glucan particles (YGP) in a model of metastatic-like melanoma in the lung, through a mechanism that is independent of previously reported β-glucan-mediated antitumor pathways. Notably, efficacy is independent of adaptive immunity, but requires inflammatory monocytes. YGP-activated monocytes mediated direct cytotoxicity against tumor cells in vitro, and systemic YGP treatment upregulated inflammatory mediators, including TNFα, M-CSF, and CCL2, in the lungs. Collectively, these studies identify a novel role for inflammatory monocytes in β-glucan-mediated antitumor efficacy, and expand the understanding of how this immunomodulator can be used to generate beneficial immune responses against metastatic disease.

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Citations

Oct 18, 2019·Biomaterials Science·Xiankang HuJianxiang Zhang
Jul 28, 2019·International Journal of Molecular Sciences·Anne GellerJun Yan
Oct 31, 2020·Cell·Lydia KalafatiTriantafyllos Chavakis
Apr 15, 2020·International Journal of Biological Macromolecules·Priscilla Barbosa Sales AlbuquerqueLuana Cassandra Breitenbach Barroso Coelho
Feb 11, 2021·Recent Patents on Anti-cancer Drug Discovery·Yu YanXiaoyu Li

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