Beta-glucuronidase activity in the bile of gallstone patients both with and without duodenal diverticula

Scandinavian Journal of Gastroenterology
V SkarM Osnes

Abstract

Patients with juxtapapillary duodenal diverticula have an increased occurrence of calcium bilirubinate gallstones. One possible hypothesis to explain this observation is enzymatic deconjugation of bilirubin conjugates in the bile. Beta-glucuronidase of human or bacterial origin may lead to deconjugation of the bilirubin glucuronides in bile. This, in turn, may increase the amounts of unconjugated, water-insoluble bilirubin which can precipitate as calcium bilirubinate, the main component of brown pigment stones. In this study we compared gallstone patients with and without duodenal diverticula treated with endoscopic papillotomy. Increased occurrence of bacteria producing beta-glucuronidase (p less than 0.01) and increased activity of bacterial beta-glucuronidase (pH 7.0) in the bile itself (p less than 0.01) were found in patients with duodenal diverticula. When the activity of the enzyme at pH 4.5, the optimum of the human enzyme, was measured, no such difference was found. The results support the hypothesis of bacterial glucuronidase as an etiologic factor in pigment gallstone disease in patients with duodenal diverticula. The high activity of bacterial enzyme found in the bile in some patients without diverticula suggests b...Continue Reading

References

Aug 1, 1975·The American Journal of Digestive Diseases·B W Trotman, R D Soloway
Jul 1, 1988·Gut·R H Kennedy, M H Thompson
Jan 1, 1988·Scandinavian Journal of Gastroenterology·V SkarJ H Strømme
Aug 1, 1987·Digestive Diseases and Sciences·H OyabuF Nakayama
May 1, 1985·Scandinavian Journal of Gastroenterology·V SkarM Osnes
Nov 1, 1984·The Japanese Journal of Surgery·N SuzukiT Sato
Sep 1, 1982·Scandinavian Journal of Gastroenterology·A R RosselandA O Aasen
Mar 8, 1980·The Medical Journal of Australia·C LeinkramG A Kune
Jul 1, 1982·Annals of Surgery·T LøtveitS Larsen
Aug 1, 1982·Scandinavian Journal of Gastroenterology·T Løtveit
Mar 1, 1981·Digestive Diseases and Sciences·M Tabata, F Nakayama

❮ Previous
Next ❯

Citations

Oct 2, 2004·Pediatric Surgery International·Kenitiro KanekoYukio Ogura
Mar 29, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H PerezJ P Luzio
Jun 11, 1999·The British Journal of Surgery·D N LoboB J Rowlands
May 1, 1992·Journal of Gastroenterology and Hepatology·T Sauerbruch
Jan 1, 1997·Journal of Gastroenterology and Hepatology·G ChandyI C Roberts-Thomson
May 23, 2012·Digestive Diseases and Sciences·Erkan ParlakBurhan Sahin
Jul 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·T OsnesM Osnes
Aug 9, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Panagiotis KatsinelosJannis Kountouras
Jul 19, 2008·Gastrointestinal Endoscopy·Vasilios PanterisSpiridon Rizos
Jul 3, 2015·The British Journal of Radiology·J J LeeB Sreeharsha
Jan 15, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rajani SharmaShubha Rani Sharma
Jul 1, 1993·The Australian and New Zealand Journal of Surgery·M D Kelly, T B Hugh
Jul 20, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Karn WijarnpreechaPatompong Ungprasert
Jun 23, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong Woo HaHye Kyung Jeon
Dec 22, 1999·The American Journal of Gastroenterology·D K LeeS P Lee
Nov 26, 2002·The British Journal of Surgery·S E Tranter, M H Thompson
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Yining WangJunbo Hong
Jul 1, 1994·Scandinavian Journal of Gastroenterology·T Juvonen
Jan 1, 2016·Euroasian Journal of Hepato-gastroenterology·Necati ÖrmeciKubilay Çınar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.