Jul 1, 1974

Beta-glucuronidase response of cells infected with Adenovirus types 5 and 12

Infection and Immunity
D Bardell, T G Metcalf

Abstract

Beta-glucuronidase activity was investigated during a 48-h period in which virus replication and changes in cell morphology occurred. Infection of an established line of chimpanzee liver cells with either nononcogenic adenovirus 5 or highly oncogenic adenovirus 12 under one-step growth conditions produced differing patterns of enzyme activity. There was an increase in total activity and also enhanced leakage of beta-glucuronidase from cells infected with adenovirus 12. In contrast, the enzymatic pattern of cells infected with adenovirus 5 was similar to that of uninfected cells. Hydrocortisone prevented the abnormal release of beta-glucuronidase from adenovirus 12-infected cells. The compound had no effect on total enzyme activity or on virus replication and the development of cytopathology.

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Mentioned in this Paper

Extravasation
Cytopathogenic Effect, Viral
Virus Replication
One-Step Dentin Bonding System
Beta-glucuronidase
Pan troglodytes
Exo-beta-D-Glucuronidase
Enzyme Activity
GUSB
Blood Enzyme Activity (Lab Test)

About this Paper

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