Beta-glycoglycosphingolipid-induced augmentation of the anti-HBV immune response is associated with altered CD8 and NKT lymphocyte distribution: a novel adjuvant for HBV vaccination

Vaccine
Meir MizrahiY Ilan

Abstract

Non-responsiveness towards the currently used hepatitis B virus (HBV) vaccine is a major problem in attempts to protect against HBV infection. Several methods have been tested to overcome the lack of an effective immune response towards HBV antigens. Adjuvants that augment the immunologic reaction are essential components of the vaccines. Beta-glycosphingolipids exert a natural killer T cell (NKT)-mediated immunomodulatory effect in various disorders. The aim of the present study was to test the ability of these compounds to augment the immune response towards HBV antigens, making them potential adjuvants for HBV vaccines. Six groups of mice were injected with different formulations of an HBV vaccine, along with various doses of beta-glucosylceramide (beta-GC), beta-lactosylceramide (beta-LC), or a combination of both (IGL) in different doses. The effect of beta-glycosphingolipids on the immune response towards HBV was tested by fluorescence-activated cell sorting analysis of hepatic and splenic NKT and CD8 lymphocytes, and serum cytokine levels. Beta-sphingolipid treatment altered the hepatic NKT and CD8 lymphocyte distribution. beta-LC, beta-GC, and the combination of both augmented anti-HBV immunity, increasing both the anti...Continue Reading

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Citations

Jul 24, 2015·Hepatology International·Yaron Ilan
Dec 2, 2014·Pathogens·Agnieszka LawrenczykWeiming Yuan
Jan 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ying-Ju LinFuu-Jen Tsai
Aug 12, 2009·Clinical and Experimental Immunology·W ZhangM E Gershwin
Sep 21, 2017·F1000Research·Cihan Yurdaydin
Sep 10, 2020·Hepatology Communications·Yuval IshayYaron Ilan
Jan 10, 2021·Journal of Digestive Diseases·Jian GanJun Feng Li
Nov 16, 2016·Blood Cells, Molecules & Diseases·Tomer AdarAri Zimran

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