Beta-interferon protects multiple sclerosis patients against enhanced susceptibility to infections caused by poor air quality

Neuroepidemiology
Mervi K Oikonen, Juha-Pekka Erälinna

Abstract

The monthly multiple sclerosis relapse rate was studied from January 1995 to March 2001 from hospital records in Southwestern Finland as a retrospective open-label study. The relapse rates of beta-interferon users and nonusers were compared to ambient air inhalable particle levels and viral infections in the population with logistic regression. In the non-user group, relapses were more frequent 1 month following the episodes when PM(10) was in the highest quartile [logistic regression odds ratio = 1.196 (95% CI = 1.019-1.404), p = 0.028] and following adenovirus epidemics in the general population [logistic regression odds ratio = 2.234 (95% CI = 1.013-4.926), p = 0.046]. PM(10) and virus infections had no significant effects in interferon users. In addition to being antiviral, interferon also protected multiple sclerosis patients against an enhanced susceptibility to infections caused by PM(10).

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Citations

Mar 2, 2010·Expert Review of Neurotherapeutics·Klaus Lauer
Jan 19, 2015·Cytokine & Growth Factor Reviews·A BertolottoM Caldano
Feb 27, 2017·Medical Hypotheses·Sayed Esmaeil MousaviMohammad Ali Sahraian
Jan 8, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Mervi OikonenAimo Salmi
May 18, 2020·Neurology. Neuroimmunology and Neuroinflammation·Joseph R BergerAmit Bar-Or
Dec 24, 2018·Frontiers in Immunology·Chelsea A O'Driscoll, Joshua D Mezrich
Nov 2, 2020·Environmental Research·Zahra NoorimotlaghSeyyed Abbas Mirzaee
Aug 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sahand AbbaszadehAmirreza Azimi

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