PMID: 8985656Oct 1, 1996Paper

Beta-lactam stability in frozen microdilution PASCO MIC panels using strains with known resistance mechanisms as biosensors

Diagnostic Microbiology and Infectious Disease
S ValdezateR Canton

Abstract

The stability of amoxicillin/clavulanate, piperacillin/tazobactam, cefepime, imipenem, and meropenem in PASCO (PASCO System, DIFCO Laboratories, Detroit, MI, USA) frozen microdilution susceptibility panels stored for 16 weeks at -20 degrees C and -70 degrees C was evaluated. The increase in MIC values for the five American-Type Culture Collection (ATCC) quality control strains for susceptibility testing recommended by the National Committee for Clinical Laboratory Standards (NCCLS) and for 13 strains with different well-characterized resistance mechanisms was indicative of bioactivity deterioration. The overall agreement (+/- 1 twofold dilution) at purchase between the MIC values of PASCO frozen microdilution susceptibility panels and the standard agar dilution method was 97.7%. Minimum inhibitory concentration values for the associations of amoxicillin/clavulanate and piperacillin/tazobactam remained unchanged for the study period at -70 degrees C. In contrast, a carbapenem bioactivity decrease was detected only with strains having well-characterized resistance mechanisms from the 12th week onwards. At -20 degrees C, antibiotic deterioration with these latter strains was observed earlier than with ATCC strains: the activity of...Continue Reading

References

May 1, 1989·Reviews of Infectious Diseases·I Brook
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Aug 1, 1986·The Journal of Infectious Diseases·J P QuinnS A Lerner
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Citations

Jul 1, 1997·Diagnostic Microbiology and Infectious Disease·M R Jacobs, S Bajaksouzian
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Andrea S GershonUNKNOWN Canadian Bacterial Surveillance Network
Dec 22, 2016·The Journal of Antimicrobial Chemotherapy·Sylvia ValdezateJuan A Saéz-Nieto

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