PMID: 6396837Jan 1, 1984Paper

Beta-lactam therapy of osteomyelitis and septic arthritis

Scandinavian Journal of Infectious Diseases. Supplementum
R B Wilber

Abstract

The goal of therapy in osteomyelitis is to eradicate established bone infection and to prevent progression into the chronic form. Beta-lactams generally lack organ toxicity or serious side effects when used in high doses for the prolonged intervals necessary to eradicate osteomyelitis. Also, the spectrum of many beta-lactams covers the usual etiologic agents of bone and joint infections. Penetration of beta-lactams into joint fluid is variable but adequate. The significance of measurable "bone levels" is unclear. Staphylococcus aureus in some series accounts for up to 80% of acute haematogenous osteomyelitis, and anti-staphylococcal penicillins and cephalosporins are the drugs of choice in these cases. Other clinical types of osteomyelitis and septic arthritis are associated with a wider range of etiologies. Factors such as the age of the patient (neonates with Gram-negative infections, infants with Haemophilus influenzae arthritis), host defense status (sickle cell patients with Salmonella osteomyelitis) as well as the site of infection (vertebral osteomyelitis associated with UTI), have an increased frequency of causes other than staphylococci, necessitating broader coverage. If environmental contamination has been introduced...Continue Reading

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