PMID: 11921490Mar 30, 2002Paper

Beta-lactam/beta-lactamase inhibitor combinations in empiric management of pediatric infections

The Journal of International Medical Research
D Adam

Abstract

Beta-lactam antibiotics have long played a central role in the management of pediatric infections. However, widespread beta-lactam resistance among community- and hospital-acquired pathogens, mainly due to beta-lactamase production, has reduced the usefulness of these trusted and well-tolerated agents. Many regions have reported an increase in beta-lactamase-mediated resistance to cephalosporins and carbapenems as well as penicillins among clinically important Gram-positive and Gram-negative aerobes and anaerobes. For some pathogens such as Moraxella catarrhalis, Klebsiella species and Pseudomonas aeruginosa, virtually all strains worldwide are beta-lactamase producers. The development of beta-lactamase inhibitors for co-administration with a number of established beta-lactam agents has restored their usefulness in pediatric patients. The combination of ampicillin plus sulbactam has broad anti-aerobic and anti-anaerobic activity in vitro and achieves high concentrations in many body tissues and fluids. The availability of a mutual oral prodrug, sultamicillin, has enabled the development of an oral formulation. Excellent clinical response and bacterial eradication rates with ampicillin/sulbactam and sultamicillin have been demon...Continue Reading

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Citations

Aug 30, 2008·Expert Opinion on Drug Delivery·Sampath C Abeylath, Edward Turos
Nov 29, 2011·The Journal of International Medical Research·H NazikF Tabak
Apr 28, 2021·Biopharmaceutics & Drug Disposition·Kubra DurkanFatma Yurt

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