PMID: 9428009Jan 15, 1998Paper

Beta-lactoglobulin suppresses melanogenesis in cultured human melanocytes

Pigment Cell Research
M NakajimaH Hayasawa

Abstract

The effects of whey proteins from bovine milk on melanogenesis in cultured human melanocytes were examined. Among the major protein components of milk whey including beta-lactoglobulin (BLG), alpha-lactalbumin, serum albumin, and IgG, only BLG exhibited the depigmenting effect at a concentration of 1 mg/ml. Also, BLG suppressed the activity of tyrosinase in these cells. Retinol, to which BLG is known to bind, slightly increased the pigmentation of the cells at concentrations in the range of 1-100 nM, and retinoic acid, a metabolite of retinol, exhibited a strong pigmentation-promoting effect within the same concentration range. Treatment of the cells with 1 mg/ml BLG completely abrogated the pigmentation induced by these A vitamins. These results demonstrate a novel biological activity of BLG and suggest that this activity is dependent on its ability to bind retinol.

References

Sep 15, 1988·Biochemical and Biophysical Research Communications·M EdwardR M MacKie
Sep 23, 1980·Biochimica Et Biophysica Acta·R D Fugate, P S Song
Jan 1, 1994·Advances in Experimental Medicine and Biology·R M Niles

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Citations

Oct 8, 2008·Bioscience, Biotechnology, and Biochemistry·Kazuomi SatoMasaru Toriyama
Nov 7, 2006·Pigment Cell Research·Francisco SolanoGhanem Ghanem
Apr 17, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Roshanak HaririTahmineh Akbarzadeh

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