Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

Nature Medicine
C SotoB Frangione

Abstract

Inhibition of cerebral amyloid beta-protein deposition seems to be an important target for Alzheimer's disease therapy. Amyloidogenesis could be inhibited by short synthetic peptides designed as beta-sheet breakers. Here we demonstrate a 5-residue peptide that inhibits amyloid beta-protein fibrillogenesis, disassembles preformed fibrils in vitro and prevents neuronal death induced by fibrils in cell culture. In addition, the beta-sheet breaker peptide significantly reduces amyloid beta-protein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. These findings may provide the basis for a new therapeutic approach to prevent amyloidosis in Alzheimer's disease.

References

Jan 1, 1978·Annual Review of Biochemistry·P Y Chou, G D Fasman
Jun 5, 1980·The New England Journal of Medicine·G G Glenner
Mar 1, 1994·Neurobiology of Aging·T WisniewskiB Frangione
Oct 1, 1994·Journal of Neurochemistry·C SotoN C Inestrosa
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Lorenzo, B A Yankner
Apr 8, 1993·Nature·G ForloniF Tagliavini
Nov 1, 1995·Trends in Biochemical Sciences·P J ThomasP L Pedersen
Feb 1, 1996·Current Opinion in Structural Biology·J W Kelly
Sep 24, 1996·Biochemical and Biophysical Research Communications·C SotoB Frangione
Mar 1, 1997·Nature Biotechnology·W P EslerJ E Maggio
Apr 16, 1998·Alzheimer Disease and Associated Disorders·R InzelbergA D Korczyn

❮ Previous
Next ❯

Citations

Jun 29, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·A B ClippingdaleC J Barrow
Apr 11, 2013·Seminars in Immunopathology·Sang Won Park, Umut Ozcan
Dec 18, 2010·Journal of Computer-aided Molecular Design·Shiri StemplerHanoch Senderowitz
Aug 10, 2002·Current Neurology and Neuroscience Reports·Thomas Wisniewski, Einar M Sigurdsson
Mar 19, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·H Akiko PopielYoshitaka Nagai
Jan 24, 2004·Biochimica Et Biophysica Acta·Lee StanyerChristopher C T Smith
Jul 11, 2006·Biochemical and Biophysical Research Communications·Sungmun LeeTheresa Good
Dec 23, 2003·Neuroscience Research·Takahiro SuemotoTohru Sawada
Nov 20, 2003·Trends in Biotechnology·Samantha Lien, Henry B Lowman
Feb 15, 2002·Brain Research·Carme CasalJosep M Tusell
Jan 11, 2001·Pharmacology & Therapeutics·K Yamada, T Nabeshima
Dec 21, 2002·Pharmacology & Therapeutics·Yoshihisa Kitamura, Yasuyuki Nomura
Dec 10, 2002·Neurobiology of Aging·Virginia M-Y Lee
Dec 10, 2002·Neurobiology of Aging·Einar M SigurdssonBlas Frangione
Jan 6, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T HarkanyC Nyakas
Jan 11, 2001·Biophysical Chemistry·J Masel, V A Jansen
Nov 15, 2002·Molecular and Cellular Endocrinology·Jo W M HöppenerCees J M Lips
May 7, 1999·Brain Research Bulletin·B S Shastry, F J Giblin
Sep 2, 2003·Current Opinion in Structural Biology·Jody M MasonAndrew J Doig
Jan 23, 1999·Current Opinion in Structural Biology·R W Carrell, B Gooptu
Apr 5, 2001·Trends in Molecular Medicine·C Soto, G P Saborío
Jan 22, 2003·Biochimica Et Biophysica Acta·Euridice P VieiraHelmuth Möhwald
Apr 20, 2013·ACS Applied Materials & Interfaces·Carolina AduraMarcelo J Kogan
Dec 22, 2012·ACS Chemical Neuroscience·Risto CukalevskiSara Linse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.