PMID: 9172012Dec 1, 1996Paper

beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination

International Journal of Immunopharmacology
Patrick J D BouicP P van Jaarsveld

Abstract

The phytosterols, beta-sitosterol (BSS), and its glucoside (BSSG) enhance the in vitro proliferative response of T-cells stimulated by sub-optimal concentrations of phytohaemagglutinin (PHA) several fold at extremely low concentrations (femtogram level). A 100:1 (mass:mass) ratio of BSS:BSSG (termed essential sterolin formulation, ESF) showed higher stimulation than the individual sterols at the same concentration. In vivo activity of ESF was also demonstrated when volunteers ingested ESF for 4 weeks. Proliferation of their T-cells, stimulated maximally with PHA, was significantly enhanced (20-920%) when compared to baseline values. In vitro, ESF (1 microgram.ml) was able to significantly enhance the expression of CD25 and HLA-Dr activation antigens on T-cells and increased the secretion, into the medium, of IL-2 and gamma interferon. NK-cell activity was also increased by BSS and BSSG alone, but with EST a higher activity was always found at different effector:target ratios (100:1 12:1).

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Citations

Sep 1, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Michio Shimamura
Jun 9, 2005·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Nov 5, 2013·Journal of Ethnopharmacology·Bhekumthetho NcubeJohannes Van Staden
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