Abstract
The beta2-adrenoreceptor agonist, clenbuterol, has been shown to spare spinal cord tissue and enhance locomotor recovery in an experimental model of spinal cord contusion injury. A likely mechanism of neurodegeneration following spinal cord injury involves generation of toxic levels of reactive oxygen species (ROS), e.g., O2-*, H2O2 and OH*, which overwhelm endogenous antioxidants. Agents, such as clenbuterol, that oppose neurodegeneration and improve recovery of locomotor function may possibly act by improving redox status. Consistent with reduced oxidative stress by beta2-agonist treatment following injury, prior blockade of synthesis of the antioxidant tripeptide, glutathione, with buthionine sulfoximine completely inhibited the ability of clenbuterol to enhance locomotor recovery and spare spinal cord tissue. Moreover, at 8 h postinjury, clenbuterol caused an increase in glutathione reductase activity, an indicator of cellular redox status, at the injury site that was also blocked by buthionine sulfoximine. Although clenbuterol improved locomotor recovery only when administered within a therapeutic window of several days postinjury, the accumulation of protein carbonyls in the spinal cord at 1 week postinjury, a consequence...Continue Reading
References
Jan 1, 1992·Journal of Neurotrauma·J A Gruner
Sep 30, 1988·Science·M F BarbeW J Welch
Apr 1, 1985·Experimental Neurology·L J Noble, J R Wrathall
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Nov 1, 1993·Journal of Neurochemistry·Z Pan, R Perez-Polo
Jan 1, 1994·Methods in Enzymology·A Z Reznick, L Packer
Jun 1, 1996·Experimental Neurology·D M BassoJ C Bresnahan
Apr 15, 1996·Brain Research·J E BarkerJ B Clark
Sep 1, 1996·Journal of Neuroimmunology·C X WangJ Gybels
Nov 18, 1996·Brain Research·K WadaH Chigasaki
Mar 3, 1997·Neuroreport·T ToyodaK S Lee
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H NawashiroJ M Hallenbeck
Oct 31, 1998·Gastroenterology·Y XuM J Czaja
Dec 3, 1998·Gastroenterology·A ColellJ C Fernández-Checa
Mar 30, 1999·The Journal of Spinal Cord Medicine·B H Juurlink, P G Paterson
May 25, 1999·Neuroscience·Y ZhuJ Krieglstein
Sep 16, 1999·Experimental Neurology·R J ZemanJ D Etlinger
Nov 17, 1999·The European Journal of Neuroscience·L SchnellV H Perry
Aug 3, 2000·Gene Therapy·K ShimazakiN Kawai
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H KamencicB H Juurlink
Feb 24, 2001·Journal of Neurotrauma·T ChikawaK Fukuzawa
Oct 5, 2001·The Journal of Spinal Cord Medicine·E D Hall
Oct 30, 2001·Experimental Neurology·R J ZemanJ D Etlinger
Nov 27, 2001·Neuroscience·Y ZhuJ Krieglstein
May 7, 2002·Journal of Neurotrauma·Marina AksenovaJames W Geddes
Jun 12, 2002·Molecular and Cellular Neurosciences·C LagordA Logan
Jun 12, 2002·Free Radical Biology & Medicine·Akira NakajimaToshitaka Nabeshima
Dec 25, 2002·Free Radical Biology & Medicine·Danxia LiuJing Wen
Jun 20, 2003·Spinal Cord·O N Hausmann
Aug 9, 2003·Journal of Neurotrauma·E SchültkeB H J Juurlink
Sep 30, 2003·Journal of Neuroscience Research·William D WhetstoneLinda J Noble-Haeusslein
Jan 13, 2004·Brain Research·Junli YeCheng He
Jan 22, 2004·Biochemical and Biophysical Research Communications·Lisa M LandinoKelly L Kennett
Apr 3, 2004·Stroke; a Journal of Cerebral Circulation·Carsten CulmseeJosef Krieglstein
Apr 30, 2004·Journal of Neurotrauma·Michael D NorenbergAlex Marcillo
Jun 23, 2004·The Journal of Biological Chemistry·Jung-Hee Jang, Young-Joon Surh
Jan 28, 2005·Journal of Neurotrauma·Virany H HillardRichard J Zeman
Citations
Jun 17, 2010·Pflügers Archiv : European journal of physiology·Fusheng BaiRichard J Zeman
Jan 7, 2014·PloS One·Binbin ChenJunyan Yao
Feb 22, 2014·PloS One·D Ryan OrmondMeena Jhanwar-Uniyal
Apr 18, 2007·Journal of Neurosurgery. Spine·Virany H HillardRichard J Zeman
Dec 10, 2013·Journal of Neurosurgery. Spine·Abraham BrownRichard J Zeman
Apr 18, 2014·Journal of Immunology Research·Lynda PetersonPatrick Flood
May 9, 2009·Neuroreport·Richard J ZemanChristopher P Cardozo
Nov 14, 2008·Neurosurgery·Richard J ZemanJoseph D Etlinger
Oct 4, 2018·Journal of Neurotrauma·Natalie E ScholpaRick G Schnellmann
Feb 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li QianPatrick M Flood
Jun 19, 2019·Journal of Neurotrauma·Stefanie LemmensSven Hendrix
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Runzhi HuangJie Zhang