Beta2 integrin mediates entry of a bacterial toxin into T lymphocytes

Cell Host & Microbe
Timothy L Cover

Abstract

Helicobacter pylori secretes a pore-forming toxin, VacA, that can cause numerous alterations in gastric epithelial cells and T lymphocytes. In this issue of Cell Host & Microbe, Sewald and colleagues report that beta2 integrin (CD18) mediates entry of VacA into human T cells. Downregulation of T cell responses by VacA may allow H. pylori to evade the adaptive immune response and establish persistent infection.

References

Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
Dec 17, 2003·The Journal of Experimental Medicine·Marianna BoncristianoCosima T Baldari
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark S SundrudTimothy L Cover
Mar 11, 2005·Nature Reviews. Microbiology·Timothy L Cover, Steven R Blanke
Nov 1, 2006·Infection and Immunity·Holly M Scott AlgoodTimothy L Cover
Oct 19, 2007·Nature·Martin J Blaser, Denise Kirschner

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Citations

Apr 17, 2016·Current Opinion in Cell Biology·Jeffrey M Williams, Billy Tsai

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