PMID: 11454137Jul 17, 2001Paper

Betablocker treatment in diabetes mellitus

Journal of Internal Medicine
P T Sawicki, A Siebenhofer

Abstract

Betablockers have been convincingly shown to reduce total and cardiovascular morbidity and mortality of hypertensive diabetic patients. In diabetic patients, after myocardial infarction, these agents confer a twice as high protective effect when compared to non-diabetic patients. However, most paradoxically, betablocking agents are used less frequently in diabetes. Control of hypertension is insufficient in most of the diabetic patients, probably because a combination of antihypertensive agents including betablockers is frequently needed to sufficiently control blood pressure but is not used in these patients. The fear of betablocker-associated side effects in diabetes may be partly responsible for the frequent antihypertensive mono-therapy and the resulting poor quality of blood pressure control among diabetic patients. We have performed an analysis of the literature to assess whether possible adverse metabolic effects, a higher risk of hypoglycaemia or less nephroprotective effects of beta1-selective betablocking agents could justify the reticence in prescribing these antihypertensive agents to diabetic patients. A thorough review of the literature does not indicate that beta1-selective betablocking agents have important adve...Continue Reading

References

Aug 1, 1975·Metabolism: Clinical and Experimental·J L Day
Feb 8, 1992·BMJ : British Medical Journal·S BjörckM Aurell
Jan 11, 1990·European Heart Journal·J KjekshusJ Ross
Apr 7, 1990·BMJ : British Medical Journal·S RössnerC D Furberg
Apr 5, 1980·British Medical Journal·A H BarnettP J Watkins
May 1, 1983·Diabetes Care·T Gundersen, J Kjekshus
Mar 26, 1982·JAMA : the Journal of the American Medical Association
Oct 1, 1994·European Journal of Clinical Investigation·P T Sawicki, M Berger
May 1, 1994·Current Opinion in Nephrology and Hypertension·H H Parving, P Rossing
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T KishimotoH Klinkmann
Jun 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·B W KarlsonA Hjalmarson
Jan 1, 1997·European Journal of Clinical Investigation·S GudbjörnsdóttirP Lönnroth
Jul 2, 1997·JAMA : the Journal of the American Medical Association·R I ShorrM R Griffin
Nov 5, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P T Sawicki
Apr 20, 1999·JAMA : the Journal of the American Medical Association·K GuM I Harris
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·F Collado-MesaJ H Fuller

Citations

Jun 3, 2009·Current Heart Failure Reports·Michael R MacDonaldJohn J V McMurray
Jun 8, 2011·Metabolic Syndrome and Related Disorders·Naohiko Ueno, Yoshiko Satou
Feb 1, 2011·Cardiovascular Diabetology·Jan Westerink, Frank L J Visseren
Oct 14, 2008·European Journal of Internal Medicine·Priska VonbachJürg H Beer
Nov 9, 2015·Autonomic Neuroscience : Basic & Clinical·Ana Barbara Alves-WagnerUbiratan Fabres Machado
Jul 4, 2006·The American Journal of Cardiology·Gregory W BarsnessBARI 2D Trial Investigators
Jan 13, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Andrew T YoungPeter M Schulman
Apr 22, 2008·European Heart Journal·Michael R MacDonaldJohn J V McMurray
Oct 27, 2004·Anesthesia and Analgesia·Daniel R Brown, Michael J Brown
Feb 7, 2003·Journal of Human Hypertension·P M NilssonSteering Committee of the National Diabetes Register, Sweden
Oct 5, 2006·Current Opinion in Anaesthesiology·Stephen F Dierdorf
Jul 25, 2019·European Journal of Hospital Pharmacy. Science and Practice·Frederik VandenbergheNicolas Schaad

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

The Journal of Clinical Hypertension
Mariela Glandt, Zachary T Bloomgarden
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Maziar AbdolrasulniaJeroan Allison
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Pamela B DeGuzmanGeorge A Beller
© 2021 Meta ULC. All rights reserved