Betaine supplementation and blood lipids: fact or artifact?

Nutrition Reviews
Steven H Zeisel

Abstract

Betaine supplementation in humans has been shown to lower plasma homocysteine concentrations in modestly hyperhomocysteinemic patients. Betaine treatment is associated with increased plasma low-density-lipoprotein (LDL) cholesterol, suggesting that although betaine supplementation lowers homocysteine, a risk factor for cardiovascular disease, changes in blood lipids may have a counterbalancing effect. However, whether the betaine effect on LDL concentration is a clinically significant problem that should change treatment options or is simply an artifact needs further study.

Citations

Jun 19, 2009·Journal of Medicinal Chemistry·Václav VanekJirí Jirácek
Jul 13, 2011·PloS One·Michael LeverStephen T Chambers
Mar 4, 2009·European Journal of Nutrition·Shiwei LvHuilian Zhu
May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Feb 27, 2015·Journal of Agricultural and Food Chemistry·Mette Skou HedemannKnud Erik Bach Knudsen

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