Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway

Pesticide Biochemistry and Physiology
E AhmadianA Eftekhari

Abstract

Organophosphates (OP) are potent pesticide commonly utilized in agricultural and domestic use. However, plentitude of data represent their side effects in different body tissues. We attempted to study whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes. Cell viability, lactate dehydrogenase (LDH) leakage, reactive oxygen species (ROS) formation, lipid peroxidation (LPO), glutathione (GSH) depletion and mitochondrial depolarization were tested as toxicity markers. The outcomes revealed that betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs and protected mitochondria after chlorpyrifos (CPF) (300μM), diazinon (DZN) (600μM) and dichlrovos (DDVP) (400μM) treatment. Taken together, all data suggests the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection.

Citations

Jul 5, 2019·Microbial Biotechnology·María Alejandra Guerrero-RubioFernando Gandía-Herrero
Aug 14, 2020·Journal of Toxicology and Environmental Health. Part a·Camila Araújo MirandaFábio Erminio Mingatto
Oct 1, 2020·Critical Reviews in Food Science and Nutrition·Davi Vieira Teixeira da SilvaVania Margaret Flosi Paschoalin
Jul 28, 2020·Biological Trace Element Research·Mohammad Mehdi OmmatiReza Heidari
Nov 27, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tarek K MotawiNoha N Nasr
Dec 18, 2019·Environmental Science and Pollution Research International·Aziz EftekhariMohammad Ali Eghbal
Aug 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Reza HeidariHossein Niknahad
Aug 19, 2021·International Journal of Environmental Health Research·Manuel Iván Girón-PérezMartín G Theumer
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aziz EftekhariMohammad Hasanzadeh

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