DOI: 10.1101/497255Dec 17, 2018Paper

BetaScan2: Standardized statistics to detect balancing selection utilizing substitution data

BioRxiv : the Preprint Server for Biology
Katherine M Siewert, Benjamin F Voight


The recently reported statistic β detects balanced haplotypes without the need for genomic data from an outgroup species. Here we present an extension to the method that incorporates between-species substitution data into the β statistic framework. We show that this approach outperforms existing summary statistics in simulations. We also present the variance of β with and without substitution data, allowing calculation of a standardized score. Besides providing a measure of significance, this enables a proper comparison of β values across varying underlying parameters, a feature lacking from some related methods.

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