Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

Journal of Translational Medicine
Tao LiuFeng Chen

Abstract

It is generally acknowledged that drug dependence is connected with abnormal functional organization in the individual's brain. The present study aimed to identify the anterior cingulate cortex (ACC) abnormality with the cerebral networks involved in betel quid dependence (BQD) by resting-state functional connectivity (rsFC) using functional magnetic resonance imaging (fMRI). With fMRI data measured from 33 resting-state BQD individuals and 32 non-addicted and age-, sex-, education-matched healthy controls, we inquired into the BQD-related changes in FC between the regions of ACC with the whole brain involved in BQD individuals using a region of interest vised method, and to identify the relation of the alteration with the severity of BQD and duration. Compared to controls, the BQD group showed increased connectivity from ACC to the regions of the reward network (brainstem including midbrain regions such as the ventral tegmental area and pons, caudate, thalamus) and cerebellum. Decreased connectivity was observed in the BQD group in regions from ACC to the default mode network (medial prefrontal cortex and precuneus) and para Hippocampal/hypothalamus. Specifically, the BQD scale was positively correlated with increased FC of ri...Continue Reading

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Citations

Dec 7, 2017·Frontiers in Psychiatry·Xiaojun HuangZhening Liu
Aug 22, 2017·Frontiers in Psychiatry·Fulai YuanWeihua Liao
Oct 28, 2017·Frontiers in Psychiatry·Fulai YuanCanhua Jiang
Apr 8, 2020·Frontiers in Psychiatry·Adellah SariahXiaojun Huang
Sep 18, 2020·International Journal of Environmental Research and Public Health·Suzanne M de la MonteAyumi Saito
Feb 15, 2017·Frontiers in Psychology·Xueling ZhuFulai Yuan
Nov 21, 2019·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Rooban ThavarajahUmadevi Krishnamohan Rao
Jan 28, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wei-Ran ZhouGuang-Heng Dong
Nov 17, 2020·Frontiers in Human Neuroscience·Zhaoxin QianFulai Yuan

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Software Mentioned

REST
Alpha Sim
Statistical Parametric Mapping
WFU PickAtlas Tool
SDS
SAS
PickAtlas
SPM8
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