Better approach for autoimmune pulmonary alveolar proteinosis treatment: inhaled or subcutaneous granulocyte-macrophage colony-stimulating factor: a meta-analyses

Respiratory Research
Gaohong ShengHui-Lan Zhang

Abstract

Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare pulmonary disease caused by functional deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF therapy in aPAP has been reported effective in some studies. This meta-analyses aimed to evaluate whether GM-CSF therapy, including inhaled and subcutaneous GM-CSF have therapeutic effect in aPAP patients. We analyzed 10 studies searched from PubMed, EmBase, Web of Science, Wiley Online Library and Cochrane Collaboration databases to evaluate the pooled effects of GM-CSF treatment in aPAP patients. Ten observational studies involving 115 aPAP patients were included. The pooled analyses of response rate (81%, p < 0.001), relapse rate (22%, p = 0.009), PaO2 (13.76 mmHg, p < 0.001) and P(A-a)O2 (19.44 mmHg, p < 0.001) showed that GM-CSF treatment was effective on aPAP patients. Further analyses showed that inhaled GM-CSF treatment was more effective than subcutaneous GM-CSF therapy, including a higher response rate (89% vs. 71%, p = 0.023), more improvements in PaO2 (21.02 mmHg vs. 8.28 mmHg, p < 0.001) and P(A-a)O2 (19.63 mmHg vs. 9.15 mmHg, p < 0.001). As two routes of exogenous GM-CSF treatment, inhaled and subcutaneous were both proven to have effect o...Continue Reading

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Citations

Feb 13, 2020·International Journal of Molecular Sciences·Kiyoharu FukushimaHiroshi Kida
May 5, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stéphane JouneauMathieu Lederlin
Jun 9, 2020·Expert Opinion on Pharmacotherapy·Sabina Antonela AntoniuIleana Antohe
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Apr 4, 2021·International Journal of Molecular Sciences·Miriam HetzelNico Lachmann
Jul 10, 2021·Journal of Medical Case Reports·Abdalla Mohmed AlasiriRabab Nasir Badri
Aug 20, 2021·Therapeutics and Clinical Risk Management·Hira IftikharAnupam Kumar
Dec 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Nadia Milad, Mathieu C Morissette

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
lavage
biopsy
bronchoalveolar lavage

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