Better outcomes of modified myeloablative conditioning without antithymocyte globulin versus myeloablative conditioning in cord blood transplantation for hematological malignancies: A retrospective (development) and a prospective (validation) study

International Journal of Cancer. Journal International Du Cancer
Zimin SunZu-yi Wang

Abstract

Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) was added to Bu/Cy and cytarabine (CA) to TBI/Cy for a modified myeloablative conditioning (MMAC). To compare the prognosis of MMAC with MAC, we conducted a retrospective study including 58 patients who underwent CBT with MAC or MMAC from 2000 to 2011. Neutrophil and platelet engraftment rate, overall survival (OS) and disease free survival (DFS) were significantly higher in the MMAC group (adjusted hazard ratio [HR], 2.58, 2.43, 0.36 and 0.37; p < 0.01, p = 0.01, p = 0.02 and p = 0.02, separately). Nonrelapse mortality (NRM) was comparable (p = 0.183). To validate the outcomes noted in the MMAC group, we conducted a prospective single-arm clinical trial including 188 patients who underwent CBT with MMAC from 2011 to 2015. Engraftment rate, survival and NRM of the MMAC group in the prospective trail (MMAC-P) were similar to the MMAC group in the retrospective study (MMAC-R). This study is the first to demonstrate th...Continue Reading

References

Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jan 16, 2008·Bone Marrow Transplantation·H NarimatsuUNKNOWN Nagoya Blood and Marrow Transplantation Group (NBMTG)
Jun 19, 2010·The Lancet Oncology·Mary EapenUNKNOWN National Cord Blood Program of the New York Blood Center
Dec 8, 2010·British Journal of Haematology·Cécile RénardGérard Michel
Feb 12, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Craig SauterJuliet N Barker
May 24, 2011·Stem Cells International·Anna D Petropoulou, Vanderson Rocha
Jun 28, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Xiang-Yu ZhaoXiao-Jun Huang
Jul 7, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfMary Eapen
Dec 12, 2012·Bone Marrow Transplantation·R OlssonO Ringden
Dec 21, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Prakash SatwaniMitchell S Cairo
Dec 21, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takehiko MoriUNKNOWN Kanto Study Group for Cell Therapy
Mar 8, 2014·Frontiers in Immunology·Robert Danby, Vanderson Rocha
Apr 8, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ling GeXiaowen Tang
Sep 10, 2014·American Journal of Hematology·Harshabad SinghYi-Bin Chen
Nov 8, 2014·Stem Cells Translational Medicine·Javier MunozElizabeth J Shpall
May 20, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Takaaki KonumaUNKNOWN Adult Myelodysplastic Syndrome and Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Tr
Jun 3, 2015·Blood·Yasuyuki AraiUNKNOWN AML and MDS Working Group of the Japan Society for Hematopoietic Cell Transplantation
Jul 15, 2015·Blood·Laurent PascalUNKNOWN Eurocord and the European Society for Blood and Marrow Transplantation
Sep 8, 2016·The New England Journal of Medicine·Filippo MilanoColleen Delaney
Nov 24, 2016·American Journal of Hematology·Hideki NakasoneUNKNOWN Complication Working Group of Japanese Society for Hematopoietic Cell Transplantation
Apr 12, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Noga Shem-TovAvichai Shimoni
Jun 24, 2017·Frontiers in Immunology·Anne M DickinsonHans Jochem-Kolb

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS

Software Mentioned

SPSS

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Blood
Yasuyuki AraiAML and MDS Working Group of the Japan Society for Hematopoietic Cell Transplantation
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
J SanzG F Sanz
© 2022 Meta ULC. All rights reserved