Better preservation of memory span relative to supraspan immediate recall in Alzheimer's disease

Neuropsychologia
Barbara J CherryVictor W Henderson

Abstract

It is suggested that Alzheimer's disease (AD) patients are able to recall more items on the digit span task than on immediate free recall from a supraspan word list. Two experiments were undertaken to verify this assertion and to understand the basis of the putative span/supraspan discrepancy. The first experiment, involving 35 mildly or moderately demented AD patients, confirmed that digit span significantly exceeded immediate recall from a 10-item supraspan word list. Although digit span also exceeded supraspan recall in 38 elderly non-demented control subjects, the discrepancy was significantly greater within the AD group. In a second experiment, 19 AD cases and 20 controls were assessed with a word span task that used nouns matched by frequency and word length to nouns on the supraspan task. The magnitude of the span/supraspan discrepancy was reduced, indicating that part of the initial discrepancy was due to differences in stimulus items (digits versus common nouns). As before, AD subjects recalled more words on the span task than the supraspan task. However, in striking contrast, NC subjects recalled more words on the supraspan task, further indicating that AD patients are particularly impaired on supraspan recall. Using ...Continue Reading

References

Dec 1, 1991·Brain : a Journal of Neurology·A D BaddeleyH Spinnler
Mar 1, 1987·Brain and Language·R G Morris
Jul 1, 1985·Brain and Language·A MartinP Fedio
Nov 1, 1967·British Journal of Psychology·B B Murdock
Aug 1, 1995·Journal of Clinical and Experimental Neuropsychology·R Antonelli IncalziP U Carbonin
Mar 1, 1995·Journal of Experimental Psychology. Learning, Memory, and Cognition·S Dehaene, R Akhavein
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Baddeley
Dec 1, 1994·Psychonomic Bulletin & Review·G R Loftus, M E Masson

❮ Previous
Next ❯

Citations

Feb 24, 2005·Journal of Neurology·Grégoria KalpouzosBéatrice Desgranges
Dec 6, 2005·Neuropsychology Review·Michal Harciarek, Krzysztof Jodzio
Feb 15, 2013·Applied Neuropsychology. Adult·Beyon H MiloyanJulia Chung
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Sandra WeintraubDavid P Salmon
Sep 10, 2013·Revue neurologique·P AllainC Verny
Jan 1, 2007·Dementia & Neuropsychologia·Marcia Lorena Fagundes Chaves, Ana Luiza Camozzato
Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Katharine K BrewsterBret R Rutherford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved