Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
K-D KimJ-B Kim

Abstract

Metabolic syndromes are prevalent worldwide and result in various complications including obesity, cardiovascular disease and type II diabetes. Betulinic acid (BA) is a naturally occurring triterpenoid that has anti-inflammatory properties. We hypothesized that treatment with BA may result in decreased body weight gain, adiposity and hepatic steatosis in a diet-induced mouse model of obesity. Mice fed a high-fat diet and treated with BA showed less weight gain and tissue adiposity without any change in calorie intake. Gene expression profiling of mouse tissues and cell lines revealed that BA treatment increased expression of lipid oxidative genes and decreased that of lipogenesis-related genes. This modulation was mediated by increased AMP-activated protein kinase (AMPK) phosphorylation, which facilitates energy expenditure, lipid oxidation and thermogenic capacity and exerts protective effects against obesity and nonalcoholic fatty liver disease. Overall, BA markedly inhibited the development of obesity and nonalcoholic fatty liver disease in mice fed a high-fat diet, and AMPK activation in various tissues and enhanced thermogenesis are two possible mechanisms underlying the antiobesity and antisteatogenic effects of BA. The c...Continue Reading

Citations

Aug 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qian MuZhiguo Zhang
Nov 3, 2020·European Journal of Medicinal Chemistry·Liu LiuHongbin Sun
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sook In ChaeJeung-Whan Han
Feb 1, 2021·Chinese Journal of Natural Medicines·Ying-Rong LengHao Zhang
Feb 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Logesh RajanSuresh Kumar Mohankumar
May 8, 2021·Natural Product Research·Atsumi ShimadaMasanori Inagaki
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Martina S SavovaMilen I Georgiev

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