Between-centre variability versus variability over time in DXA whole body measurements evaluated using a whole body phantom

European Journal of Radiology
Olivia LouisJean De Schepper

Abstract

This study aimed to compare the variability of whole body measurements, using dual energy X-ray absorptiometry (DXA), among geographically distinct centres versus that over time in a given centre. A Hologic-designed 28 kg modular whole body phantom was used, including high density polyethylene, gray polyvinylchloride and aluminium. It was scanned on seven Hologic QDR 4500 DXA devices, located in seven centres and was also repeatedly (n=18) scanned in the reference centre, over a time span of 5 months. The mean between-centre coefficient of variation (CV) ranged from 2.0 (lean mass) to 5.6% (fat mass) while the mean within-centre CV ranged from 0.3 (total mass) to 4.7% (total area). Between-centre variability compared well with within-centre variability for total area, bone mineral content and bone mineral density, but was significantly higher for fat (p<0.001), lean (p<0.005) and total mass (p<0.001). Our results suggest that, even when using the same device, the between-centre variability remains a matter of concern, particularly where body composition is concerned.

References

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Citations

Jan 14, 2010·Clinical Pharmacokinetics·Teun M PostMeindert Danhof
May 24, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Derek PearsonDesmond J Green
Feb 19, 2008·The Journal of Pediatrics·Jean De SchepperFrancis de Zegher
Nov 30, 2007·Medicine and Science in Sports and Exercise·Ville M MattilaHarri Pihlajamäki
Jan 11, 2019·The Journal of Clinical Endocrinology and Metabolism·Husam GhanimParesh Dandona
Dec 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Husam GhanimParesh Dandona

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