Bevacizumab-induced atypical hemolytic uremic syndrome and treatment with eculizumab

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Anusha VakitiKelly W Fitzpatrick

Abstract

Bevacizumab (Avastin) is a recombinant humanized monoclonal antibody used for the management of various solid malignancies including colorectal, lung, brain, renal, and ovarian cancers as well as age-related macular degeneration of the eye. It is a vascular endothelial growth factor inhibitor which exhibits its action by blocking the growth of blood vessels in cancerous tissue. Common side effects include hypertension, fatigue, headaches, and increased risk of infections. Atypical hemolytic uremic syndrome is a serious side effect associated with bevacizumab due to its anti-angiogenic effect. It encompasses the clinical triad of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure, without any association with Shiga toxins. Eculizumab is a terminal complement inhibitor used in the treatment of atypical hemolytic uremic syndrome. Herein, we present three cases of bevacizumab-induced atypical hemolytic syndrome treated successfully with eculizumab.

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Citations

Jun 13, 2020·Frontiers in Medicine·Thomas ChatzikonstantinouEleni Gavriilaki
Mar 31, 2021·The Cochrane Database of Systematic Reviews·Dan PughDavid Kavanagh
Apr 17, 2021·Translational Oncology·Patrícia ValérioJosé Maximino Costa
Jul 31, 2021·World Journal of Gastroenterology : WJG·Hsuan YehTzung-Hai Yen

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BETA
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biopsy

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