Beverage-specific effects of ethanol consumption on its biological markers

Clinical Chemistry and Laboratory Medicine : CCLM
Hidenari SakutataTeizo Ito

Abstract

Serum gamma-glutamyltransferase (GGT) and erythrocyte mean corpuscular volume (MCV) are well-known biological markers of excessive ethanol consumption. The beverage-specific effects of ethanol consumption on GGT level and MCV value were analyzed cross-sectionally and retrospectively among middle-aged Japanese men who underwent a retirement health checkup (n = 974). Both the consumption of distilled alcohol and that of fermented alcohol positively correlated with the logarithm of GGT [standard regression coefficient (beta) 0.261 and 0.174, respectively]. The prevalence rate of elevated GGT levels > or = 70 IU/L) was higher among heavy drinkers of distilled alcohol than among heavy drinkers of fermented alcohol (38.8% vs. 27.6%, p = 0.013). The MCV value correlated with distilled alcohol consumption (beta: 0.212, p < 0.0001) but not with fermented alcohol consumption (beta: 0.043, not significant). The prevalence rate of an elevated MCV (> or = 97 fL) was higher among heavy drinkers of distilled alcohol than among heavy drinkers of fermented alcohol (35.3% vs. 16.8%, p < 0.001). These results suggest that MCV is less sensitive for detecting heavy consumption of fermented alcohol than for detecting that of distilled alcohol in app...Continue Reading

References

Dec 15, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Mario Plebani
Apr 9, 2010·Alcoholism, Clinical and Experimental Research·Willard M Freeman, Kent E Vrana
Jun 13, 2017·Frontiers in Psychiatry·Jennifer L TempleMiriam A Mestre
Jul 5, 2019·Public Health Nutrition·Christine D CzoliDavid Hammond
Sep 21, 2016·Nutrients·Mari Mohn PaulsenLene Frost Andersen

Citations

Aug 1, 1990·American Journal of Epidemiology·O NilssenT Brenn
Apr 1, 1994·American Journal of Epidemiology·S KonoK Hatsuse
May 25, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S BleichJ Kornhuber
Jul 12, 2001·American Journal of Epidemiology·A de BreeD Kromhout
Dec 6, 2001·Annals of Clinical Biochemistry·P C Sharpe
Jul 27, 2002·European Journal of Clinical Nutrition·Ligia E DíazA Marcos
May 23, 2003·Drug and Alcohol Dependence·Svetlana Skurtveit, Aage Tverdal
Feb 27, 2004·Addiction·Katherine M ConigraveJohn B Whitfield
Apr 2, 2005·Journal of Radiation Research·Manami MonobeShuji Kojima
Jun 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Clarissa Gerhäuser
Oct 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Onni Niemelä
May 2, 2007·International Journal of Food Sciences and Nutrition·Shela GorinsteinSimon Trakhtenberg
Sep 11, 2007·Journal of the American College of Cardiology·James H O'KeefeCarl J Lavie
Nov 21, 2007·The British Journal of Nutrition·Javier RomeoAscensión Marcos

Related Concepts

Ethanol
Ethanol Measurement
Gamma-glutamyl transferase
Gamma Glutamyl Transferase Measurement
Alcohol Abuse
Mean Corpuscular Hemoglobin Concentration Determination
Statistical Sensitivity
Viral Markers
Erythrocyte Mean Corpuscular Volume Measurement
Pure Red-Cell Aplasia

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.