Dec 8, 2015

Beyond cell proliferation in avian facial morphogenesis

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Marta Linde-MedinaRalph S Marcucio


The upper jaw in vertebrates forms from several prominences that arise around the stomodeum or primitive mouth. These prominences undergo coordinated growth and morphogenesis to fuse and form the face. Undirected, regionalized cell proliferation is thought to be the driving force behind the morphogenesis of the facial prominences. However, recent findings suggest that directed cell behaviors in the mesenchyme (e.g., directed cell division, directed cell movement, convergent extension) might be required for successful face formation. Here we discuss the evidence for this view and how directed behaviors may interact with the basement membrane to regulate morphogenesis of the facial region. We believe that future research in these largely unexplored areas could significantly impact our understanding of facial morphogenesis.

  • References1
  • Citations34


  • References1
  • Citations34

Mentioned in this Paper

Cell Movement
Cell Motility
Cell Division
Region of Face
Cell Proliferation

Related Feeds

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Rulang JiangAndrew C Lidral
Deutsche zahnärztliche Zeitschrift
R Werner
Current Opinion in Genetics & Development
Chong Pyo Choe, J Gage Crump
Methods in Cell Biology
R Craig Albertson, Pamela C Yelick
© 2020 Meta ULC. All rights reserved