Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma

Bone Marrow Transplantation
N LendvaiH J Cho

Abstract

Autologous hematopoietic cell transplantation (auto-HCT) is the standard consolidation therapy for plasma cell myeloma patients following induction therapy. Auto-HCT improves disease-free survival (DFS), but is generally not curative. The allogeneic HCT experience demonstrated that T-cell immunotherapy can confer long-term DFS. Preclinical and clinical data indicate that myeloma-associated Ags elicit humoral and cellular immune responses (IRs) in myeloma patients. These findings strongly suggest that the immunotherapeutic strategies, including immune checkpoint inhibitors, therapeutic cancer vaccines and adoptive cellular therapies, are promising avenues of clinical research that may be most applicable in the minimal residual disease state following auto-HCT. These strategies are designed to prime or augment antimyeloma IRs and promote a 'host-vs-myeloma' effect that may result in durable DFS. Innovative clinical trials investigating immune checkpoint inhibitors and cancer vaccines have demonstrated that robust immunity against myeloma-associated Ags can be elicited in the setting of auto-HCT. A diverse array of immunotherapeutic strategies have entered clinical trials in myeloma, including PD-1/PD-L1 inhibitors, DC/myeloma cel...Continue Reading

References

Nov 6, 1998·The Journal of Experimental Medicine·R DyallJ Nikolić-Zugić
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L ChenV Cerundolo
Dec 29, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·A LisoR Levy
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E KeoghA Sette
Aug 7, 2001·Seminars in Hematology·W I BensingerR Storb
Jun 28, 2002·Nature Immunology·Jackson G EgenJames P Allison
Aug 30, 2002·Blood·Jaime O ClaudioA Keith Stewart
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Madhav V DhodapkarKara Olson
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
May 27, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Carol Ann HuffRichard J Jones
Jun 11, 2003·The Journal of Experimental Medicine·Madhav V DhodapkarJoseph Krasovsky
Nov 25, 2003·Blood·William MatsuiRichard J Jones
Nov 26, 2003·The Journal of Experimental Medicine·Madhav V DhodapkarMatthew D Geller
Sep 2, 2006·Science·Richard A MorganSteven A Rosenberg
Jan 11, 2007·The Journal of Experimental Medicine·Bin ZhangHans Schreiber
Jan 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·John KorethEdwin P Alyea
Feb 3, 2007·The Journal of Clinical Investigation·Claudia WrzesinskiNicholas P Restifo
Jul 28, 2007·The Journal of Clinical Investigation·Chrystal M PaulosNicholas P Restifo
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola NeriNoopur Raje
Jan 4, 2008·Cancer Research·William MatsuiRichard J Jones
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Oct 14, 2008·Bone Marrow Transplantation·R L OlinE A Stadtmauer
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oihana MurilloIgnacio Melero
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba

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Citations

Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Oct 21, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Adam D Cohen

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