Beyond EGFR Targeting in SCCHN: Angiogenesis, PI3K, and Other Molecular Targets

Frontiers in Oncology
Esma Saada-Bouzid, Christophe Le Tourneau

Abstract

Although the molecular landscape of squamous cell carcinoma of the head and neck (SCCHN) has been largely deciphered, only one targeted therapy has been approved to date without any molecular selection, namely cetuximab. Cetuximab is a monoclonal antibody targeting EGFR. It has been shown to improve overall survival in the locally advanced setting in combination with radiotherapy and the recurrent and/or metastatic setting in combination with a platinum compound and 5FU. Beside EGFR targeting agents, antiangiogenic agents have been shown to produce antitumor activity but were associated with substantial toxicity. Buparlisib that targets PI3K was also shown to improve survival in combination with paclitaxel in an unselected patient population. Several other targeted therapies have been developed in SCCHN, most of time in all comers, potentially explaining the limited efficacy reported with them. The recent emergence of clinical trials of targeted therapies in enriched patient populations and precision medicine trials such as umbrella trials might boost the clinical development of targeted therapy in SCCHN.

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Citations

Jul 31, 2020·Molecular Cancer Therapeutics·Mara GilardiFrancis Burrows
Aug 8, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Robert KleszczJarosław Paluszczak

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Methods Mentioned

BETA
acetylating
biopsy

Clinical Trials Mentioned

NCT03719690
NCT03088059
NCT03179956
NCT03356587
NCT02499120
NCT03065062
NCT02706691
NCT02419417
NCT02465060
NCT02693535

Software Mentioned

TAPUR
UPSTREAM
PALATINUS

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