Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety

Experimental Biology and Medicine
Claudio GentiliPietro Pietrini

Abstract

Patients with social anxiety disorder (SAD) experience anxiety and avoidance in face-to-face interactions. We performed a meta-analysis of functional magnetic resonance imaging (fMRI) studies in SAD to provide a comprehensive understanding of the neural underpinnings of face perception in this disorder. To this purpose, we adopted an innovative approach, asking authors for unpublished data. This is a common procedure for behavioral meta-analyses, which, however has never been used in neuroimaging studies. We searched Pubmed with the key words "Social Anxiety AND faces" and "Social Phobia AND faces." Then, we selected those fMRI studies for which we were able to obtain data for the comparison between SAD and healthy controls (HC) in a face perception task, either from the published papers or from the authors themselves. In this way, we obtained 23 studies (totaling 449 SAD and 424 HC individuals). We identified significant clusters in which faces evoked a higher response in SAD in bilateral amygdala, globus pallidus, superior temporal sulcus, visual cortex, and prefrontal cortex. We also found a higher activity for HC in the lingual gyrus and in the posterior cingulate. Our findings show that altered neural response to face in S...Continue Reading

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Citations

Feb 3, 2016·Current Psychiatry Reports·Ulrich Stangier
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Janna Marie Bas-HoogendamP Michiel Westenberg
Oct 5, 2016·Depression and Anxiety·Andrea L GoldJennifer C Britton
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Apr 30, 2017·Depression and Anxiety·Annmarie MacNamaraK Luan Phan
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Aug 9, 2020·Frontiers in Psychiatry·Benjamin KreifeltsDirk Wildgruber
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Dec 29, 2020·Brain and Behavior·Johannah Bashford-LargoKarina S Blair
Oct 24, 2020·Scientific Reports·Bonni CrawfordAndrew D Lawrence
Oct 16, 2020·Cognitive Neuropsychiatry·Emilie Bäcklin LöwenbergJohan Lundin Kleberg
May 1, 2021·Brain Sciences·Corinna HartlingSimone Grimm
Jun 4, 2021·Frontiers in Psychiatry·Johan Lundin KlebergJens Högström
May 26, 2021·Translational Psychiatry·Giorgia DegasperiClaudio Gentili
May 18, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vivien GüntherThomas Suslow
Jul 4, 2021·NeuroImage. Clinical·Laura Finlayson-ShortChristopher Davey
Jul 21, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lorenzo Lucherini AngelettiGeorg Northoff

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Methods Mentioned

BETA
cognitive behavioral therapy

Software Mentioned

GingerALE
MNI

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