Beyond Equilibrium Phase Diagrams: Enzymatic Activity Shakes Up Bacterial Condensates

Molecular Cell
Stefan BiedzinskiStephanie C Weber

Abstract

Phase separation is a thermodynamic process, but cells are inherently out of equilibrium. Guilhas et al. (2020) identify an active process through which an ATP-dependent motor controls the number and position of biomolecular condensates in bacteria.

References

Feb 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anthony G VecchiarelliKiyoshi Mizuuchi
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chase P BroederszNed S Wingreen
Apr 10, 2018·Biophysical Journal·Fabian Erdel, Karsten Rippe
Sep 11, 2018·Molecular Cell·Nadra Al-HusiniJared M Schrader
Dec 14, 2019·Cell·Manuel Osorio-ValerianoMartin Thanbichler
May 28, 2020·Trends in Biochemical Sciences·Megan C Cohan, Rohit V Pappu
Jul 18, 2020·Molecular Cell·Baptiste GuilhasMarcelo Nollmann

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Citations

Nov 14, 2020·Biophysical Journal·Christopher A AzaldeguiJulie S Biteen
Aug 17, 2021·Current Opinion in Cell Biology·Adrián Merino-SalomónPetra Schwille

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