Beyond genomic selection: The animal model strikes back (one generation)!

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
R J CantetS Munilla

Abstract

Genome inheritance is by segments of DNA rather than by independent loci. We introduce the ancestral regression (AR) as a recursive system of simultaneous equations, with grandparental path coefficients as novel parameters. The information given by the pedigree in the AR is complementary with that provided by a dense set of genomic markers, such that the resulting linear function of grandparental BV is uncorrelated to the average of parental BV in the absence of inbreeding. AR is then connected to segmental inheritance by a causal multivariate Gaussian density for BV. The resulting covariance structure (Σ) is Markovian, meaning that conditional on the BV of parents and grandparents, the BV of the animal is independent of everything else. Thus, an algorithm is presented to invert the resulting covariance structure, with a computing effort that is linear in the number of animals as in the case of the inverse additive relationship matrix.

References

Sep 1, 1973·Theoretical Population Biology·C C Cockerham, B S Weir
Jul 19, 2008·Theoretical Population Biology·Frederick A Matsen, Steven N Evans
Oct 24, 2008·Journal of Dairy Science·P M VanRaden
May 16, 2012·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S Munilla, R J C Cantet
Oct 30, 2012·American Journal of Human Genetics·Pier Francesco PalamaraItsik Pe'er
Jul 6, 2014·Genetics·Asko Mäki-Tanila, William G Hill
Nov 8, 2015·Theoretical Population Biology·J KelleherN H Barton
Dec 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Siddharth Krishna KumarShripad Tuljapurkar
May 3, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·N S FornerisR J C Cantet
Sep 28, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·C A García-BaccinoR J C Cantet

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Citations

May 1, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Meiyue Wang, Shizhong Xu

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