PMID: 9427655Mar 7, 1998Paper

Beyond guanine quartets: cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine

Chemistry & Biology
C RobertsC Switzer

Abstract

iso-Guanine (iso-G) is the purine component of an isomeric Watson-Crick base pair that may have existed prebiotically. By comparing the abiotic molecular recognition properties of iso-G and its complement, iso-cytosine (iso-C), with those of genomic nucleotide bases, it may be possible to explain the exclusion of the iso-G-iso-C base pair from modern genomes. Whether a nucleobase forms quartets may have a key role in determining its functionality. Biotically, nucleic acid tetraplexes have been implicated in cellular functions; prebiotically, tetraplexes would probably interfere with replication. Recently, in vitro selection has yielded receptors and catalysts that incorporate G quartets. The versatility of these structures could be enhanced by expanding the range of bases that can form the quartet motif. Native polyacrylamide gel electrophoresis of oligonucleotides bearing runs of iso-G provides strong support for tetraplex formation via cation-promoted DNA strand association. In particular, when strands of different lengths bearing the same iso-G tetrad recognition element were combined, five bands were observed after electrophoresis, corresponding to all possible heterotetraplexes with parallel strand alignment. An analogous ...Continue Reading

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Citations

Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J C Chaput, C Switzer
Jun 22, 2010·Journal of Mass Spectrometry : JMS·Emilie-Laure ZinsDetlef Schröder
Jan 8, 1999·Journal of Molecular Biology·N V HudJ Feigon
Jun 10, 2017·Chemical Reviews·Wenhu ZhouJuewen Liu
Jun 20, 2018·Chemistry, an Asian Journal·Fan TangQianming Chen
Apr 5, 2014·Angewandte Chemie·Valentina AbetRaphaël Rodriguez
Oct 9, 2016·Biopolymers·Jen-Yu LiaoJohn C Chaput
Oct 5, 2018·Physical Chemistry Chemical Physics : PCCP·Armağan KaratosunAdem Tekin
Mar 31, 2007·Journal of Computational Chemistry·Jiande GuJerzy Leszczynski
Nov 6, 2008·Chembiochem : a European Journal of Chemical Biology·Benjamin D Heuberger, Christopher Switzer
Sep 12, 2009·Chemistry : a European Journal·Sarah E PierceJennifer S Brodbelt
Feb 13, 2010·Chemistry & Biodiversity·Junya Chiba, Masahiko Inouye
Apr 23, 2008·Current Protocols in Nucleic Acid Chemistry·Floyd E RomesbergAllison A Henry
Aug 20, 2011·Chemistry : a European Journal·Vijay SinghJörg S Hartig
Mar 10, 2009·Angewandte Chemie·Brooke A Rosenzweig, Andrew D Hamilton
Jul 28, 2020·Quarterly Reviews of Biophysics·Ali NikoomanzarJohn C Chaput
Aug 2, 2011·Chembiochem : a European Journal of Chemical Biology·Ragan BuckleyNicholas V Hud
Feb 27, 2009·Journal of Combinatorial Chemistry·Subba Rao NallagatlaChristopher Switzer
Jan 8, 2004·Journal of the American Chemical Society·José Ramón BlasModesto Orozco

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