Beyond homeostasis: a predictive-dynamic framework for understanding cellular behavior.

Annual Review of Cell and Developmental Biology
Peter L Freddolino, Saeed Tavazoie

Abstract

Microbial regulatory strategies have long been understood in terms of the homeostatic framework, in which a response is interpreted as a restoring force counteracting the immediate intracellular consequences of a change in the environment. In this review, we summarize the breadth of recent discoveries of cellular behavior extending beyond the homeostatic framework. We argue that the nonrandom structure of native habitats makes environmental fluctuations inherently multidimensional. Beyond its utility for accurate perception of immediate events, the temporal regularity of this multidimensional correlation structure allows microbes to make predictions about the trajectory of their sensory environment. We describe recently discovered examples of such predictive behavior, their physiological benefits, and the underlying evolutionary forces shaping them. These observations compel us to go beyond homeostasis and consider a predictive-dynamic framework in which cellular behavior is orchestrated in response to the meaning of an environmental perturbation, not only its direct and immediate fitness consequences.

References

Jun 15, 1995·Genes & Development·Y LiuT Kondo
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Ruis, C Schüller
Jun 1, 1996·Molecular Microbiology·M Eisenbach
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·W Boos, H Shuman
Jul 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D ThieffryJ Collado-Vides
Mar 6, 1999·Current Opinion in Microbiology·J J Loros
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 17, 2001·Molecular Biology of the Cell·H C CaustonR A Young
Mar 23, 2002·Science·Daniel E Koshland
Jul 26, 2002·Nature·Guri GiaeverMark Johnston
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter S SwainEric D Siggia
May 31, 2003·Journal of Bacteriology·Heather R Bonifield, Kelly T Hughes
Apr 1, 1959·Experimental Cell Research·P A STEWART, B T STEWART
Jun 1, 1961·Journal of Molecular Biology·F JACOB, J MONOD
Jan 28, 2004·The Journal of Cell Biology·Nick I MarkevichBoris N Kholodenko
Dec 15, 1950·Science·A NOVICK, L SZILARD
Feb 20, 2004·Nature·Ertugrul M OzbudakAlexander Van Oudenaarden
Mar 24, 2004·Nature Reviews. Microbiology·Susan S Golden, Shannon R Canales
May 29, 2004·Genetics·Mukund Thattai, Alexander van Oudenaarden
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Hendrik Szurmant, George W Ordal
Jul 9, 2004·Molecular Biology of the Cell·Alok J SaldanhaDavid Botstein
Jul 20, 2004·Clinical Microbiology Reviews·Marjan W van der Woude, Andreas J Bäumler
Aug 17, 2004·Science·Nathalie Q BalabanStanislas Leibler
Aug 28, 2004·Trends in Biotechnology·Marie Csete, John Doyle
Sep 17, 2004·Nature·Craig C Mello, Darryl Conte
Oct 19, 2004·Annual Review of Microbiology·Patricia L Lakin-Thomas, Stuart Brody
Jan 5, 2005·Nature Reviews. Genetics·Marjori A Matzke, James A Birchler
Feb 12, 2005·The Journal of Biological Chemistry·Mingzhu LiuFrederick R Blattner
Mar 11, 2005·Journal of Theoretical Biology·Denise M WolfAdam P Arkin
Mar 26, 2005·Science·Nitzan RosenfeldMichael B Elowitz
Mar 31, 2005·Current Opinion in Genetics & Development·Bradley R Cairns
Apr 23, 2005·Science·Susannah Green TringeEdward M Rubin
May 4, 2005·Journal of Bacteriology·Emma RedonMuriel Cocaign-Bousquet

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Citations

Jul 23, 2013·PLoS Genetics·Alison K HottesSaeed Tavazoie
May 28, 2015·Trends in Genetics : TIG·Mario A Fares
May 1, 2015·Frontiers in Microbiology·Pamela Lyon
Jul 23, 2016·Frontiers in Psychology·František Baluška, Michael Levin
Oct 23, 2016·Bio Systems·Slawomir J Nasuto, Yoshikatsu Hayashi
Apr 24, 2020·PLoS Computational Biology·Alexander TschantzChristopher L Buckley
Oct 13, 2017·Frontiers in Human Neuroscience·Paolo CavallariCarlo Bruttini
Jan 5, 2017·Clinical and Translational Medicine·William B Miller, John S Torday
Nov 1, 2016·Social Cognitive and Affective Neuroscience·Lisa Feldman Barrett
Dec 14, 2017·PLoS Biology·Yonat GurvichNaama Barkai
Jun 28, 2018·Current Genetics·Jeffrey N Carey, Mark Goulian

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Methods Mentioned

BETA
environmental stress

Software Mentioned

EVE

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