[Beyond immunopathogenesis. Insulin resistance and "epidermal dysfunction"].

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
W-H BoehnckeC Buerger

Abstract

Insulin is a central player in the regulation of metabolic as well as non-metabolic cells: inefficient signal transduction (insulin resistance) not only represents the cornerstone in the pathogenesis of type 2 diabetes mellitus, but also drives atherosclerosis through inducing endothelial dysfunction. Last but not least epidermal homeostasis depends on insulin. We summarize the effects of insulin on proliferation and differentiation of human keratinocytes as well as the relevance of cytokine-induced insulin resistance for alterations in epidermal homeostasis characteristic for psoriasis. Kinases involved in both insulin- as well as cytokine-receptor signaling represent potential targets for innovative therapeutics. Such small molecules would primarily normalize "epidermal dysfunction", thus complementing the immunomodulatory strategies of today's biologics.

References

Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Cullen M TaniguchiC Ronald Kahn
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Dec 3, 2009·Journal of Medicinal Chemistry·David M GoldsteinMichael J Soth
Jan 19, 2010·BMJ : British Medical Journal·Wolf-Henning BoehnckeMichael P Schön
Dec 21, 2010·Archives of Dermatological Research·Sandra BoehnckeWolf-Henning Boehncke
Mar 18, 2011·Experimental Dermatology·Wolf-Henning BoehnckeBrian Kirby

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Citations

Feb 26, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·J A JohnsonA W Armstrong

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