Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma.

Case Reports in Oncology
Albert GrinshpunAyala Hubert

Abstract

Pancreatic adenocarcinoma (PDAC) has a grim prognosis. Molecular and genomic analyses revealed that the striking majority of these tumors are driven by KRAS mutation, currently not amenable to targeted therapy. However, other driver mutations were found in a small fraction of patients. Herein we report of 3 cases of patients with metastatic PDAC and wildtype KRAS, found to harbor BRAF or RET pathogenic alterations. The patients were treated with targeted therapies with variable success. In our opinion, those proof-of-concept cases argue in favor of additional research and clinical trials' effort in this small but significant PDAC population with uncommon driver mutations.

References

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Citations

Jun 22, 2019·Diagnostic Pathology·Basile Tessier-CloutierDavid F Schaeffer
May 1, 2021·American Society of Clinical Oncology Educational Book·Michael S Lee, Shubham Pant

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Methods Mentioned

BETA
biopsy

Software Mentioned

GENIE

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