Breast cancer screening remains a subject of intense and, at times, passionate debate. Mammography has long been the mainstay of breast cancer detection and is the only screening test proven to reduce mortality. Although it remains the gold standard of breast cancer screening, there is increasing awareness of subpopulations of women for whom mammography has reduced sensitivity. Mammography also has undergone increased scrutiny for false positives and excessive biopsies, which increase radiation dose, cost, and patient anxiety. In response to these challenges, new technologies for breast cancer screening have been developed, including low-dose mammography, contrast-enhanced mammography, tomosynthesis, automated whole breast ultrasound, molecular imaging, and magnetic resonance imaging. Here we examine some of the current controversies and promising new technologies that may improve detection of breast cancer both in the general population and in high-risk groups, such as women with dense breasts. We propose that optimal breast cancer screening will ultimately require a personalized approach based on metrics of cancer risk with selective application of specific screening technologies best suited to the individual's age, risk, and...Continue Reading
Associated Clinical Trials
Projecting individualized probabilities of developing breast cancer for white females who are being examined annually
Mammographic parenchymal patterns and mode of detection: implications for the breast screening programme
Breast Imaging Reporting and Data System: inter- and intraobserver variability in feature analysis and final assessment
Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers
BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes
Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations
Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography
Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition
Digital breast tomosynthesis: initial experience in 98 women with abnormal digital screening mammography
Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts.
Full field digital mammography and breast density: comparison of calibrated and noncalibrated measurements
Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk
Comparison of radiologist performance with photon-counting full-field digital mammography to conventional full-field digital mammography
Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study
Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)
The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update
Contrast-Enhanced X-ray Detection of Microcalcifications in Radiographically Dense Mammary Tissue Using Targeted Gold Nanoparticles
The state of the art in breast imaging using the Twente Photoacoustic Mammoscope: results from 31 measurements on malignancies
The inter-observer variability of breast density scoring between mammography technologists and breast radiologists and its effect on the rate of adjuvant ultrasound
Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13C]pyruvate
Increased Cancer Detection Rate and Variations in the Recall Rate Resulting from Implementation of 3D Digital Breast Tomosynthesis into a Population-based Screening Program
Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study: impact on relative risk of breast cancer
Preliminary results of a new approach for three-dimensional reconstruction of Dynamic AngioThermography (DATG) images based on the inversion of heat equation
Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer
Risk stratification of women with false-positive test results in mammography screening based on mammographic morphology and density: A case control study
Underutilization of Supplemental Magnetic Resonance Imaging Screening Among Patients at High Breast Cancer Risk
Classification of fatty and dense breast parenchyma: comparison of automatic volumetric density measurement and radiologists' classification and their inter-observer variation
Dose hysteria and concern about radiation exposure should not prevent women from undergoing life-saving mammography screening
Standards-Based Clinical Decision Support Platform to Manage Patients Who Meet Guideline-Based Criteria for Genetic Evaluation of Familial Cancer.
Comparison of Mortality Among Participants of Women's Health Initiative Trials With Screening-Detected Breast Cancers vs Interval Breast Cancers.
An efficient biomarker panel for diagnosis of breast cancer using surface-enhanced laser desorption ionization time-of-flight mass spectrometry
US urban-rural disparities in breast cancer-screening practices at the national, regional, and state level, 2012-2016
Diagnostic performance of the automated breast volume scanner: a systematic review of inter-rater reliability/agreement and meta-analysis of diagnostic accuracy for differentiating benign and malignant breast lesions
Zeonex-based asymmetrical terahertz photonic crystal fiber for multichannel communication and polarization maintaining applications
Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial
Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis.
Breast Cancer Detection-A Synopsis of Conventional Modalities and the Potential Role of Microwave Imaging
Manganese-enhanced magnetic resonance imaging for early detection and characterization of breast cancers
Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Circulating immune cell populations related to primary breast cancer, surgical removal, and radiotherapy revealed by flow cytometry analysis.
Effect of image quality and motivation of radiographer teams in mammography after dedicated training and the use of an evaluation tool like PGMI.
Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.
Breast Cancer: BRCA1 & BRCA2
Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.