Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk-Based Diet

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
Amy B HairSteven A Abrams

Abstract

The aim of this study was to compare outcomes of infants pre and post initiation of a feeding protocol providing an exclusive human milk-based diet (HUM). In a multicenter retrospective cohort study, infants with a birth weight <1,250 g who received a bovine-based diet (BOV) of mother's own milk fortified with bovine fortifier and/or preterm formula were compared to infants who received a newly introduced HUM feeding protocol. Infants were excluded if they had major congenital anomalies or died in the first 12 hours of life. Data were collected 2-3 years prior to and after introduction of an exclusive HUM diet. Primary outcomes were necrotizing enterocolitis (NEC) and mortality. Secondary outcomes included late-onset sepsis, retinopathy of prematurity (ROP), and bronchopulmonary dysplasia (BPD). A total of 1,587 infants were included from four centers in Texas, Illinois, Florida, and California. There were no differences in baseline demographics or growth of infants. The HUM group had significantly lower incidence of proven NEC (16.7% versus 6.9%, p < 0.00001), mortality (17.2% versus 13.6%, p = 0.04), late-onset sepsis (30.3% versus 19.0%, p < 0.00001), ROP (9% versus 5.2%, p = 0.003), and BPD (56.3% versus 47.7%, p = 0.0015) ...Continue Reading

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Citations

Apr 8, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Arthur I Eidelman
Jun 28, 2016·The Journal of Pediatrics·Amy B Hair
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May 6, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Arthur I Eidelman
Aug 29, 2020·Pediatric Research·Amy B HairSarah N Taylor

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BETA
PMA
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