Beyond "Option B+": Understanding Antiretroviral Therapy (ART) Adherence, Retention in Care and Engagement in ART Services Among Pregnant and Postpartum Women Initiating Therapy in Sub-Saharan Africa

Journal of Acquired Immune Deficiency Syndromes : JAIDS
L Myer, T K Phillips

Abstract

Several studies from sub-Saharan Africa have highlighted significant challenges in providing antiretroviral therapy (ART) to pregnant and postpartum women, with specific concerns around maintaining optimal levels of adherence to ART and/or retaining women in long-term services. However, there are few conceptual frameworks to help understand nonadherence and nonretention, as well as the drivers of these, among HIV-infected women, particularly in the postpartum period. This review provides an overview of the key issues involved in thinking about ART adherence, retention in care and engagement in ART services among pregnant and postpartum women. The related behaviors of adherence and retention may be understood as components of effective engagement of patients in ART services, which share the goal of achieving and maintaining suppressed maternal viral load on ART. Under this framework, the existing literature indicates that disengagement from care is widespread among postpartum women, with strikingly similar data emerging from ART services around the globe and indications that similar challenges may be encountered by postpartum care services outside the context of HIV. However, the drivers of disengagement require further research...Continue Reading

References

Mar 1, 1993·Archives of Family Medicine·D K GjerdingenP M McGovern
Jul 26, 2008·BMJ : British Medical Journal·Andrew Cole
Sep 29, 2011·Annual Review of Pharmacology and Toxicology·Terrence F BlaschkeJohn Urquhart
Nov 1, 2011·PLoS Medicine·Benjamin H ChiUNKNOWN International Epidemiologic Databases to Evaluate AIDS Collaboration
Apr 11, 2012·British Journal of Clinical Pharmacology·Bernard VrijensUNKNOWN ABC Project Team
Jan 29, 2013·Lancet·Anna CoutsoudisHoosen Coovadia
Feb 5, 2013·Tropical Medicine & International Health : TM & IH·Kate ClouseMatthew P Fox
Jun 8, 2013·Current Opinion in HIV and AIDS·Katie Doherty, Andrea Ciaranello
Jul 23, 2013·Current Opinion in HIV and AIDS·Benjamin H ChiCharles B Holmes
Jan 29, 2014·AIDS·Lyson TenthaniUNKNOWN Ministry of Health in Malawi and IeDEA Southern Africa
Mar 25, 2014·Current HIV/AIDS Reports·Alison C RoxbyJudd L Walson
Jun 9, 2014·Lancet·Gary MaartensSharon R Lewin
Aug 5, 2014·Tropical Medicine & International Health : TM & IH·Hannock TweyaSam Phiri
Aug 26, 2014·Infectious Disease Clinics of North America·Ellen F EatonMichael Mugavero
Sep 14, 2014·Current HIV/AIDS Reports·Jennifer L BrownRalph J DiClemente
Sep 25, 2014·BMC Public Health·Heather BaileyUNKNOWN Ukraine European Collaborative Study Group in EuroCoord
Oct 4, 2014·Implementation Science : IS·Lore ClaessensAshraf Coovadia
Oct 11, 2014·Journal of the International AIDS Society·Tamsin PhillipsLandon Myer
Oct 14, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nigel C RollinsUNKNOWN INSPIRE Team
Jan 7, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cassidy E HenegarAnnelies Van Rie
Aug 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joëlla W AdamsFlorence M Momplaisir
Sep 20, 2015·International Journal of STD & AIDS·Hannah LoftusJulia Greig
Sep 24, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Catherine A KossSera L Young
Nov 7, 2015·AIDS·Susie HuntingtonUNKNOWN UK Collaborative HIV Cohort (UK CHIC) Study and the UK and Ireland National Study of HIV in Pregnancy and Childhood (NSHPC)
Nov 12, 2015·Tropical Medicine & International Health : TM & IH·Janet DzangareOwen Mugurungi
Dec 3, 2015·Journal of the International AIDS Society·Nicholas A MedlandChristopher K Fairley
Mar 5, 2016·The New England Journal of Medicine·Katherine Luzuriaga, Lynne M Mofenson
Jan 1, 2015·The Journal of Perinatal Education·Lorraine O WalkerFrancine Nichols
Apr 28, 2016·Journal of the International AIDS Society·Pascal GeldsetzerTill Bärnighausen
May 22, 2016·Tropical Medicine & International Health : TM & IH·Jara Llenas-GarcíaUNKNOWN SolidarMed and IeDEA-Southern Africa

❮ Previous
Next ❯

Citations

Apr 10, 2018·International Journal of STD & AIDS·Deborah L JonesKarl Peltzer
Nov 28, 2017·Journal of the International AIDS Society·Coceka N MnyaniJames A McIntyre
Dec 29, 2017·Journal of the International AIDS Society·Yegor VoroninGabriella Scarlatti
May 22, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ezekiel LuogaAnna Gamell
Mar 15, 2019·HIV Medicine·Dr Yvonne GilleeceMs Alison Wright
Nov 10, 2017·Tropical Medicine & International Health : TM & IH·Terusha ChettyAnna Coutsoudis
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karen WebbElvin Geng
Apr 28, 2020·AIDS Care·Ana Clara Cruz ZonenscheinMarcos Augusto Bastos Dias
Jul 24, 2020·International Journal of STD & AIDS·Ana R Pati PascomVivian I Avelino-Silva
Aug 18, 2020·The Pediatric Infectious Disease Journal·Elri du PlooyHelena Rabie
Oct 9, 2020·Journal of the International AIDS Society·Helene FontUNKNOWN INSPIRE group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.