Beyond rituximab: the future of monoclonal antibodies in B-cell non-Hodgkin lymphoma.
Abstract
The treatment of non-Hodgkin lymphoma (NHL) has changed dramatically since the introduction of rituximab, a monoclonal antibody that binds to the B-cell transmembrane protein CD20 and causes lysis of the lymphoma cells. Since then, a number of additional antibodies have been tested against other B-cell targets, resulting in variable efficacies. The goal of these newer agents is to achieve similar or better response rates as seen with rituximab, and perhaps demonstrate activity in rituximab-refractory disease. Several of the antibodies have been investigated in combination with each other as well as with conventional chemotherapeutic regimens. Approval of such antibodies by regulatory committees and their eventual integration into clinical practice will likely depend on positive results from randomized trials.
References
Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma
Citations
Immuno-pharmacodynamics for evaluating mechanism of action and developing immunotherapy combinations
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