[Beyond staging, typing and grading. New challenges in breast cancer pathology].

Der Pathologe
H H KreipeF Länger

Abstract

Tumor biological parameters for the prediction and prognosis of invasive breast cancer are gaining in importance compared to traditional pathological categories. The immunohistochemically determined steroid hormone receptor status is not only the decisive factor influencing whether endocrine therapy (which is indicated in cases of even slight expression) is given or not, but also whether chemotherapy is considered. The Her2 status is of similar importance and needs to be analysed in every case of invasive carcinoma, whereby reproducibility, which requires greater efforts than with steroid hormone receptors, has to be assured. Probably only a small portion of breast cancers will benefit from chemotherapy. Since traditional pathological categories are not sufficient for the identification of this subgroup, there has been an intense search for alternative prognostic parameters, whereby gene expression profiling has emerged as the most promising tool. Despite minimal concordance with regard to single genes, the various profiles available converge in the identification of the proliferative signature as the prognostically most relevant. Whether histopathological grading and immunohistochemical determination of the growth fraction wit...Continue Reading

References

Aug 30, 2000·Nature·C M PerouD Botstein
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GancbergD Larsimont
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Feb 12, 2005·Lancet·John P A Ioannidis
Jun 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColozzaM J Piccart
Aug 27, 2005·The New England Journal of Medicine·Stephan BraunKlaus Pantel
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Jun 2, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jochen GaedckeHans H Kreipe
Aug 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN 10th St. Gallen conference
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
Jan 31, 2008·Journal of the National Cancer Institute·Laura C CollinsRulla M Tamimi
Mar 25, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melina B FlanaganRohit Bhargava
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M Ignatiadis, C Sotiriou
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Nasser SrourRalf Steinert
Oct 30, 2008·Virchows Archiv : an International Journal of Pathology·Reinhard von WasielewskiHans Kreipe
Jan 10, 2009·Nature Reviews. Cancer·Barry Gusterson
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido SauterMichael F Press
Feb 21, 2009·The New England Journal of Medicine·Christos Sotiriou, Lajos Pusztai
Apr 1, 2009·Nature Reviews. Clinical Oncology·Klaus Pantel, Sabine Riethdorf
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members

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