Beyond structure, to survival: activation of Stat3 by cadherin engagement

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Leda RaptisH Feracci

Abstract

Cells in normal tissues or in tumors have extensive opportunities for adhesion to their neighbors and the importance of cell to cell contact in the study of fundamental cellular processes is beginning to emerge. In this review, we discuss recent evidence of dramatic changes in the activity of an important signal transducer found to be profoundly affected by cell to cell adhesion, the signal transducer and activator of transcription-3 (Stat3). Direct cadherin engagement, growth of cells to postconfluence, or formation of multicellular aggregates were found to induce a striking increase in the levels of Stat3 activity, Rac1/Cdc42, and members of the IL6 receptor family in different settings. This activation was specific to Stat3, in that the levels of the extracellular signal regulated kinase (Erk1/2), a signal transducer often coordinately activated with Stat3 by a number of growth factors or oncogenes, remained unaffected by cell density. Density-dependent Stat3 activation may play a key role in survival, and could contribute to the establishment of cell polarity. It is clear that at any given time the total Stat3 activity levels in a cell are the sum of the effects of cell to cell adhesion plus the conventional Stat3 activatin...Continue Reading

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Citations

Apr 12, 2012·Biology of Reproduction·Anna SokalskaAntoni J Duleba
Apr 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Anna SokalskaAntoni J Duleba
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Qinchuan WangChung-Jing J Lin
Mar 29, 2014·Cancers·Stephanie GuyLeda Raptis
Jun 10, 2014·Journal of Cellular Physiology·Vicky García-HernándezRubén G Contreras
Mar 8, 2012·Experimental Cell Research·Jonathan Michaud-LevesqueRichard Béliveau
May 31, 2011·Experimental Cell Research·Leda RaptisJames Turkson
Feb 23, 2010·Journal of Immunological Methods·Samantha GreerLeda Raptis
Oct 27, 2009·Experimental Cell Research·Rozanne ArulanandamLeda Raptis
Jan 29, 2014·JAK-STAT·Mulu GeletuLeda Raptis
Apr 2, 2013·Biochimica Et Biophysica Acta·M GeletuL Raptis
May 21, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brian C DipaoloSusan S Margulies
Apr 16, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mulu GeletuLeda Raptis
Nov 14, 2015·Biomolecular Concepts·Maximilian NiitLeda Raptis
Sep 28, 2017·International Journal of Molecular Medicine·Chien-Hung LinYann-Jang Chen

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