Beyond survival: the burden of disease in decision making in organ transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Henry KrakauerMonica J Y Lin

Abstract

Organ transplantation has long been perceived as a life-saving intervention. However, it is now recognized that the broader objectives include reducing the patient's burden of disease. The components of the burden of disease include (i) mortality, (ii) morbidity, (iii) disability, (iv) psychological distress and (v) resource use. These components may be correlated either positively or negatively, reflecting common disease antecedents or the trade-offs in clinical decisions. Our proposed approach to modeling includes measures of each outcome and, explicitly, their correlations. Its results are the predicted independent and joint probabilities that a patient will experience any specified range of each measure and of combinations of the measures. The methods were tested with data on mortality, morbidity and resource use from patients following kidney transplantation. The predicted probabilities of the measures are consistent with their observed values and distinguish among the prognoses of patients with distinctive risks, such as diabetics. We have shown, and we believe, that it is feasible to assess the interrelated components of the burden of disease in individual patients and hope that our approach may serve as a starting point...Continue Reading

References

Nov 1, 1977·Transplantation·R C BaileyJ P Summe
Apr 1, 1991·Statistics in Medicine·H Krakauer, R C Bailey
Nov 3, 1993·JAMA : the Journal of the American Medical Association·A D OxmanG H Guyatt
Apr 3, 1998·Journal of Evaluation in Clinical Practice·H KrakauerD C Schutt
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Clifton BaileyHenry Krakauer

❮ Previous
Next ❯

Citations

Sep 15, 2005·The Journal of Cardiovascular Nursing·Mary Amanda Dew, Andrea F DiMartini
Dec 23, 2004·Transplantation·Lawrence G Hunsicker
Sep 17, 2013·Transplantation Proceedings·D PaganoS Gruttadauria
Nov 22, 2012·Néphrologie & thérapeutique·Marie-France Mamzer-BruneelChristophe Legendre
Jul 18, 2008·Transplantation Reviews·Domingo HernándezJulio Pascual
Sep 15, 2012·Transplantation Proceedings·G GrossoM Veroux
May 30, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·UNKNOWN Psychosocial Outcomes Workgroup of the Nursing and Social Sciences Council of the International Society for Heart and Lung TWayne Paris
Jul 25, 2006·Lancet·Lainie Friedman RossJ Richard Thistlethwaite
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Christine WuMark Unruh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jesse D ScholdHerwig-Ulf Meier-Kriesche
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Michael L VolkJorge A Marrero
© 2021 Meta ULC. All rights reserved