Beyond the cluster: methodological and clinical implications in the Boston Area Community Health survey and EPIC studies

BJU International
Raymond C RosenChristine Thompson

Abstract

To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. Sensitivity analyses were used to assess the effects of: (i) the number of urological symptoms included in the cluster analysis; (ii) the use of ordinal vs dichotomous scaling of responses; (iii) the type of cluster analysis used (hierarchical vs non-hierarchical; random vs nonrandom seeds); and (iv) the distance metric (median difference vs root mean square) of the resulting clusters. These sensitivity analyses were conducted independently in each of the two studies, with results systematically compared using Cramer's V statistic. Contingency tables were also used to assess the frequency of transitions or change in classification from one method to another. There were marked similarities in the cluster profiles in men and women across the two studies. For both men and women, the largest clusters consisted of low-frequency, single-symptom profiles, with urinary frequency and urgency symptoms reported by both genders. There was a multiple, m...Continue Reading

References

Nov 2, 2004·Statistical Methods in Medical Research·Brian Everitt
Mar 31, 2005·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·David B HenryDeborah Gorman-Smith
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Jan 31, 2006·Journal of Pain and Symptom Management·Andrea M BarsevickWilliam N Dudley
Mar 14, 2008·BJU International·Karin S CoyneIan Milsom

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Citations

Dec 12, 2012·International Journal of Epidemiology·Rebecca S PiccoloJohn B McKinlay
May 17, 2017·International Journal of Clinical Practice·Hyun Hwan SungKyu-Sung Lee
Jul 11, 2018·The Journal of Urology·Victor P AndreevUNKNOWN LURN Study Group

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