Beyond the HPA-axis: The role of the gonadal steroid hormone receptors in modulating stress-related responses in an animal model of PTSD

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Daphna FenchelHagit Cohen

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis, which plays a major role in the response to stress, and the hypothalamic-pituitary-gonadal (HPG) axis are closely linked with the ability to inhibit the other. Testosterone, a product of the HPG, has many beneficial effects beyond its functions as a sex hormone including anti-anxiety properties. In this study we examined the effect of stress exposure on gonadal hormones, and their efficacy in modulating anxiety-like response in an animal model of PTSD. Male rats were exposed to predator scent stress, followed by analysis of brain expression of androgen receptor (AR) receptor and estrogen receptor α (ERα). The behavioral effects of immediate treatment with testosterone, testosterone receptor antagonist (flutamide) or vehicle were evaluated using the elevated plus-maze, acoustic startle response and trauma-cue response. Levels of circulating corticosterone and testosterone were also measured after treatment. The behavioral effects of delayed testosterone treatment were explored in the same manner. We report that animals whose behavior was extremely disrupted (EBR) selectively displayed significant down-regulation of AR and ERα in the hippocampus. Immediate treatment with flutamide or...Continue Reading

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Citations

Nov 3, 2016·Journal of Mental Health·Claudia Lin XiaoJayashri Kulkarni
Apr 19, 2015·Hormones and Behavior·Lisa Y Maeng, Mohammed R Milad
May 25, 2016·Molecular and Cellular Endocrinology·Cristhian MendozaValentina Echeverria
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Mar 1, 2019·Molecular Psychiatry·Gal Richter-LevinMathias V Schmidt
Apr 11, 2018·Metabolic Brain Disease·Zhi-Kun QiuJi-Sheng Chen
May 6, 2016·Journal of Psychopharmacology·Zeng-Liang JinJie Xiong
Aug 18, 2017·Learning & Memory·René Garcia
May 18, 2021·Neurobiology of Stress·Olga Y Ponomareva, Kerry J Ressler

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