Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

The Journal of General Virology
Sheryl Coutermarsh-OttIrving Coy Allen

Abstract

A complex interaction exists between elements of the host innate immune system and viral pathogens. It is essential that the host mount a robust immune response during viral infection and effectively resolve inflammation once the pathogen has been eliminated. Members of the nucleotide-binding domain leucine-rich repeat [NBD-LRR; known as NOD-like receptor (NLR)] family of cytosolic pattern-recognition receptors are essential components of these immunological processes and have diverse functions in the host antiviral immune response. NLRs can be subgrouped based on their general function. The inflammasome-forming subgroup of NLRs are the best-characterized family members, and several have been found to modulate the maturation of IL-1β and IL-18 following virus exposure. However, the members of the regulatory NLR subgroups are significantly less characterized. These NLRs uniquely function to modulate signalling pathways initiated by other families of pattern-recognition receptors, such as Toll-like receptors and/or Rig-I-like helicase receptors. Regulatory NLRs that augment pro-inflammatory pathways include nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2, which have been shown to form a multiprotein...Continue Reading

References

Jan 1, 1996·Free Radical Biology & Medicine·K B Schwarz
Jul 21, 2001·EMBO Reports·S E GirardinD J Philpott
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Apr 3, 2003·Gastroenterology·Tadakazu HisamatsuDaniel K Podolsky
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Jun 25, 2004·The Journal of Biological Chemistry·Bastian OpitzStefan Hippenstiel
Jun 29, 2004·Nature Immunology·Tomohiro WatanabeWarren Strober
Jan 18, 2005·Circulation Research·Bastian OpitzMatthias Krüll
Feb 5, 2005·Science·Koichi S KobayashiRichard A Flavell
Feb 12, 2005·The Journal of Biological Chemistry·Brian J ContiJenny P-Y Ting
Jun 22, 2005·Trends in Immunology·Fabio Martinon, Jürg Tschopp
Sep 10, 2005·The Journal of Biological Chemistry·Leonardo H TravassosMaria Cristina Plotkowski
Feb 24, 2006·Nature Reviews. Immunology·Warren StroberTomohiro Watanabe
Dec 13, 2006·The American Journal of Gastroenterology·Katsuyoshi MatsuokaToshifumi Hibi
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·John D LichJenny P-Y Ting
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jean da Silva CorreiaRichard Ulevitch
Aug 11, 2007·Seminars in Immunopathology·Ivan TattoliStephen E Girardin
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janelle C ArthurJenny P-Y Ting
Dec 15, 2007·The EMBO Journal·Mizuho HasegawaNaohiro Inohara
Jan 18, 2008·Nature·Chris B MooreJenny P-Y Ting
Feb 19, 2008·Current Opinion in Immunology·Zhengmao Ye, Jenny Pan-Yun Ting
Sep 16, 2008·Viral Immunology·Yongming SangFrank Blecha
Sep 18, 2008·The Journal of General Virology·Yu-Hsiu LeeShih-Tung Liu
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joao Gamelas MagalhaesDana J Philpott
Jan 23, 2009·Nature·Teresa Fernandes-AlnemriEmad S Alnemri
Mar 7, 2009·Biochimica Et Biophysica Acta·Sanae Shoji-Kawata, Beth Levine
Apr 2, 2009·PloS One·Roland N WagnerRobert Schwarzenbacher
Jun 9, 2009·American Journal of Respiratory Cell and Molecular Biology·Albert P SenftKevin S Harrod
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andreas KriegJohn C Reed

❮ Previous
Next ❯

Citations

Mar 21, 2018·Cancers·Timsy UppalSubhash C Verma
Mar 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shunmei HuangJun Wu
Jan 22, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Alaa Alhazmi
Oct 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle H TheusIrving C Allen
Sep 3, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aaron M TockerBeckley K Davis
Feb 2, 2018·Journal of Leukocyte Biology·Daniel E RothschildIrving C Allen
Apr 25, 2018·Cold Spring Harbor Perspectives in Medicine·Zongdi Feng, Stanley M Lemon
Apr 2, 2019·Nature Communications·Swechha M PokharelSantanu Bose
Oct 7, 2017·Current Medicinal Chemistry·Giulia FreerMauro Pistello
Apr 2, 2020·Infection and Immunity·Sharon K Kuss-Duerkop, A Marijke Keestra-Gounder
Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeremy K Y YapAkiko Iwasaki
Feb 20, 2019·Frontiers in Immunology·Bipandeep DhillonAli A Abdul-Sater
Nov 5, 2019·Frontiers in Immunology·Margaret A Nagai-SingerIrving C Allen
Dec 25, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiaomin MaLihui Han
Nov 10, 2017·Mediators of Inflammation·Danilo PagliariRossella Cianci
Jul 12, 2018·Journal of Immunology Research·David Alex Cronkite, Tara M Strutt
Aug 7, 2019·Glia·Ashley McDonough, Jonathan R Weinstein
Mar 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiao Man WuMing Xian Chang
Dec 15, 2020·Immunology·Robert J Pickering, Lee M Booty
Jan 7, 2021·The Journal of Physiology·Ciara E KeoghMélanie G Gareau
Dec 22, 2020·Frontiers in Cellular and Infection Microbiology·Tiia Snäkä, Nicolas Fasel
Feb 3, 2021·International Journal of Molecular Sciences·Tünde FeketeKitti Pázmándi
Apr 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bo He, Régis Moreau
Jul 8, 2020·Developmental and Comparative Immunology·Hong FangMing Xian Chang
Feb 20, 2018·Developmental and Comparative Immunology·Lu CaoMing Xian Chang
Apr 9, 2021·Journal of Virology·Mrinal SamantaJacques Robert
Jun 15, 2021·Animal Reproduction·Cecilia Constantino RochaGuilherme Pugliesi
Jul 25, 2021·International Journal of Molecular Sciences·Pengwei Li, Mingxian Chang
Sep 9, 2020·Developmental and Comparative Immunology·Ming Xian ChangYi Wei Hu
Oct 5, 2021·Frontiers in Immunology·Aarón Vázquez-JiménezOsbaldo Resendis-Antonio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Inflammatory Bowel Diseases
Beckley K DavisIrving Coy Allen
Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Yutaro KumagaiShizuo Akira
© 2022 Meta ULC. All rights reserved